The archaeological discourse on the development of metallurgy in Anatolia, the Levant and, more generally, the Eastern Mediterranean region has extensively focused on crucial aspects such as procurement routes, technological developments, manufacturing strategies, and socio-economic connotations of metal consumption. On the other hand, potential symbolic and ritualistic aspects permeating mining and metal-making activities have rarely been taken into consideration, largely due to the ephemerality of such traditions and practices in the material record. Extensive studies have analyzed the ritual dimensions of iron and copper metalworking across different belief systems and social structures, from pre-industrial sub-Saharan Africa to pre-classical Andean cultures, from Bronze Age Central Europe to China. Drawing on the contemporary anthropological and archaeological debate on the subject, this contribution identifies and analyzes recurrent semantics of ritualization in metalworking processes, looking at different lines of epigraphic and material evidence from the Chalcolithic and Bronze Age Eastern Mediterranean. The aim is to discuss patterns of correlation between belief systems, ritual behavior, and socioeconomic organizations and to prompt more comprehensive analyses on the complementary technological and symbolic aspects of ancient metallurgical practices.