Notch and Vascular Smooth Muscle Cell Phenotype

Abstract

Abstract-The

The mammary myoepithelial cell

“…The Notch pathway has been reported to contribute to the control of the smooth muscle phenotype (Morrow et al, 2008) and implicated in the amplification of mammary myoepithelial progenitors (Dontu et al, 2004). The impact of Notch signaling on control of the balance of smooth muscle (and, probably, myoepithelial) cell proliferation and differentiation is context dependent.…”

The miR-143/145 Cluster Is a Novel Transcriptional Target of Jagged-1/Notch Signaling in Vascular Smooth Muscle Cells

“…VSMC respond to vascular injury with decreased expression of contractile proteins and increased proliferation and migration (3). Several pathways have been identified that promote the VSMC contractile phenotype including SRF/myocardin (4), transforming growth factor ␤ (5, 6), and Notch signaling (7,8), while transcription factors such as Krüp-pel-like factor 5 (KLF5) are known to promote a proliferative phenotype by direct binding to the cyclin D1 promoter (9).…”

Aging reduces susceptibility of vascular smooth muscle cells to H2O2-induced apoptosis through the down-regulation of Jagged1 expression in endothelial cells

“…Notch signaling is significantly involved in the responses of the vasculature to injury and growth stimulation (16). Jagged1, a ligand for Notch receptors, is abundantly present in Ecs.…”