Notch signaling in the hematopoietic system

Sandy, Ashley R.; Maillard, Ivan

doi:10.1517/14712590903260777

Cited by 51 publications

(44 citation statements)

References 156 publications

(128 reference statements)

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“…[1][2][3][4] Notch signaling plays multiple roles in hematopoiesis and is essential for the establishment of definitive hematopoiesis through the generation of hematopoietic stem cells, 5 as well as for their subsequent differentiation in an expanding number of blood cell types. [6][7][8][9] The role of Notch signaling has been particularly well documented in T-cell development where Notch1/Dll4 interactions are crucial to induce T-lineage differentiation at the expense of other hematopoietic lineages. [10][11][12][13][14] Subsequently, Notch signaling is implemented in TCR-rearrangements, 15,16 modulation of TCR-αb versus -gd development, [17][18][19][20][21] and in the support of proliferation during b-selection.…”

Section: Introductionmentioning

confidence: 99%

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

et al. 2014

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Section: Introductionmentioning

confidence: 99%

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

et al. 2014

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“…Therefore, dysfunction of Notch prevents differentiation, ultimately guiding undifferentiated cells toward malignant transformation. Investigations of two last decades show that those disorders of the Notch signaling pathway are associated with development of some human haematological and solid cancers (1)(2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Association between Notch signaling pathway and cancer

Lachej¹,

Didžiapetrienė²,

Kazbarienė³

et al. 2013

AML

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Background. The components of the Notch signaling pathway are important in maintaining the balance involved in cell proliferation, apoptosis and differentiation. Therefore, dysfunction of the Notch prevents differentiation, ultimately guiding undifferentiated cells toward malignant transformation. The aim of this article is to present recently published data concerning the role of the Notch signaling pathway components in development and prognosis of oncologic diseases, in occurrence of resistance to cytostatic agents and importance in creating of new cancer treatment approaches. Materials and methods. The Pubmed was the main source of looking for information for this article. Results. Recent investigations show that disorders of the Notch signaling pathway are associated with development of some human haematological and solid cancers. In different tissues and organs this active pathway can act as a tumor suppressor or an oncogene. Accordingly, the increased or decreased expression of its components is defined. Most of published data show that the increased expression of Notch pathway components correlates with a worse prognosis of cancer and a shorter survival. Recently, the Notch pathway has been reported to be involved in drug resistance. The modulation of the Notch signaling pathway could be helpful in treatment of some tumors with abnormal activity of this pathway’s components. Therefore changes in the expression of Notch components could become important predictive factors, helpful in selecting the proper treatment method. Conclusions. The results of recent studies are very important, since the detecting of the prognostic and predictive value of components of the Notch signaling pathway can allow creating new and improving already known methods of cancer diagnostic and treatment.

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“…Interaction of Notch receptors with their ligands initiates the release of the active intracellular domain of Notch by proteolytic cleavages from the membrane, allowing its translocation into the nucleus. Once there, the intracellular domain of Notch forms a complex with recombination signal-binding protein-J, converting it from a repressor to an activator of transcription (8). There is increasing evidence revealing an important role for Notch signaling in the regulation of CD4 + Th cell differentiation or function in the periphery (9)(10)(11).…”

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confidence: 99%

Notch Signaling Regulates Follicular Helper T Cell Differentiation

Auderset

Schuster

Fasnacht

et al. 2013

The Journal of Immunology

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Follicular helper T (TFH) cells are specialized in providing help for B cell differentiation and Ab secretion. Several positive and negative regulators of TFH cell differentiation have been described but their control is not fully understood. In this study, we show that Notch signaling in T cells is a major player in the development and function of TFH cells. T cell–specific gene ablation of Notch1 and Notch2 impaired differentiation of TFH cells in draining lymph nodes of mice immunized with T-dependent Ags or infected with parasites. Impaired TFH cell differentiation correlated with deficient germinal center development and the absence of high-affinity Abs. The impact of loss of Notch on TFH cell differentiation was largely independent of its effect on IL-4. These results show a previously unknown role for Notch in the regulation of TFH cell differentiation and function with implications for the control of this T cell population.

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Notch signaling in the hematopoietic system

Cited by 51 publications

References 156 publications

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

Association between Notch signaling pathway and cancer

Notch Signaling Regulates Follicular Helper T Cell Differentiation

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