Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway

Viatour, Patrick; Ehmer, Ursula; Saddic, Louis A.; Dorrell, Craig; Andersen, Jesper B.; Lin, Chenwei; Zmoos, Anne Flore; Mazur, Paweł K.; Schaffer, Bethany E.; Ostermeier, Austin; Vogel, Hannes; Sylvester, Karl G.; Thorgeirsson, Snorri S.; Grompe, Markus; Sage, Julien

doi:10.1084/jem.20110198

Cited by 187 publications

(169 citation statements)

References 82 publications

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“…14 Notch1 signaling therefore seems to have a crucial role. Notch1 signaling also appears to have tumor suppressor roles in murine keratinocytes, 20 human pancreatic 19 and hepatocellular carcinomas 18 and small-cell lung cancer. 33 Taken together, these observations indicate that aberrant activation of the Notch1 pathway has various roles in solid tumors.…”

Section: Discussionmentioning

confidence: 99%

“…15,16 On the other hand, there is growing evidence that Notch signaling activation may have growthsuppressive functions in other hematopoietic cells, hepatocytes, the pancreatic epithelium and skin. [17][18][19][20] Several studies have indicated that upregulation of Notch signaling may contribute to the malignant phenotype in head and neck squamous cell carcinomas (HNSCCs), including those of the oral cavity. 21,22 However, some researchers have shown that Notch signaling has a tumor suppressive role.…”

mentioning

confidence: 99%

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The pathological significance of Notch1 in oral squamous cell carcinoma

Yoshida

Nagata

Nakayama

et al. 2013

Laboratory Investigation

102

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

The pathological significance of Notch1 in oral squamous cell carcinoma

Yoshida

Nagata

Nakayama

et al. 2013

Laboratory Investigation

102

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“…Patients with better survival showed significantly higher expression of Notch related genes (33). Two recent studies of head and neck squamous cell carcinoma identified mutation affecting Notch receptors.…”

Section: Notch As a Tumor Suppressor In Solid Tumorsmentioning

confidence: 95%

Association between Notch signaling pathway and cancer

Lachej¹,

Didžiapetrienė²,

Kazbarienė³

et al. 2013

AML

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Background. The components of the Notch signaling pathway are important in maintaining the balance involved in cell proliferation, apoptosis and differentiation. Therefore, dysfunction of the Notch prevents differentiation, ultimately guiding undifferentiated cells toward malignant transformation. The aim of this article is to present recently published data concerning the role of the Notch signaling pathway components in development and prognosis of oncologic diseases, in occurrence of resistance to cytostatic agents and importance in creating of new cancer treatment approaches. Materials and methods. The Pubmed was the main source of looking for information for this article. Results. Recent investigations show that disorders of the Notch signaling pathway are associated with development of some human haematological and solid cancers. In different tissues and organs this active pathway can act as a tumor suppressor or an oncogene. Accordingly, the increased or decreased expression of its components is defined. Most of published data show that the increased expression of Notch pathway components correlates with a worse prognosis of cancer and a shorter survival. Recently, the Notch pathway has been reported to be involved in drug resistance. The modulation of the Notch signaling pathway could be helpful in treatment of some tumors with abnormal activity of this pathway’s components. Therefore changes in the expression of Notch components could become important predictive factors, helpful in selecting the proper treatment method. Conclusions. The results of recent studies are very important, since the detecting of the prognostic and predictive value of components of the Notch signaling pathway can allow creating new and improving already known methods of cancer diagnostic and treatment.

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“…Accordingly, in CCA development, N1ICD association with protein kinase B signaling in hepatocytes stimulated their malignant dedifferentiation (82). The stimulation of N1ICD expression by inflammatory mediators has also been reported in human CCA, which additionally supports the role of Notch in liver cancer (83) (Table II) (9,12,24,31,(84)(85)(86)(87).…”

Section: Role Of Notch In Hcc and Icc Developmentmentioning

confidence: 59%

Oncogenic role of the Notch pathway in primary liver cancer

et al. 2016

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Abstract. Primary liver cancer, which includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, is one of the most common malignancies and the third leading cause of cancer-associated mortality, worldwide. Despite the development of novel therapies, the prognosis of liver cancer patients remains extremely poor. Thus, investigation of the genetic background and molecular mechanisms underlying the development and progression of this disease has gained significant attention. The Notch signaling pathway is a crucial determinant of cell fate during development and disease in several organs. In the liver, Notch signaling is involved in biliary tree development and tubulogenesis, and is also significant in the development of HCC and ICC. These findings suggest that the modulation of Notch pathway activity may have therapeutic relevance. The present review summarizes Notch signaling during HCC and ICC development and discusses the findings of recent studies regarding Notch expression, which reveal novel insights into its function in liver cancer progression.

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Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway

Abstract: Mice lacking all three Rb genes in the liver develop tumors resembling specific subgroups of human hepatocellular carcinomas, and Notch activity appears to suppress the growth and progression of these tumors.

Cited by 187 publications

References 82 publications

The pathological significance of Notch1 in oral squamous cell carcinoma

The pathological significance of Notch1 in oral squamous cell carcinoma

Association between Notch signaling pathway and cancer

Oncogenic role of the Notch pathway in primary liver cancer

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