2024
DOI: 10.3389/fcell.2024.1450038
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Notch signaling regulates pulmonary fibrosis

Xinyue Zhang,
Zhihao Xu,
Qi Chen
et al.

Abstract: Pulmonary fibrosis is a progressive interstitial lung disease associated with aging. The pathogenesis of pulmonary fibrosis remains unclear, however, alveolar epithelial cell injury, myofibroblast activation, and extracellular matrix (ECM) accumulation are recognized as key contributors. Moreover, recent studies have implicated cellular senescence, endothelial-mesenchymal transition (EndMT), and epigenetic modifications in the pathogenesis of fibrotic diseases. Various signaling pathways regulate pulmonary fib… Show more

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