Note: Ferrule-top atomic force microscope. II. Imaging in tapping mode and at low temperature

Chavan, D.C.; Andres, D.; Iannuzzi, Davide

doi:10.1063/1.3579496

Cited by 17 publications

(13 citation statements)

References 9 publications

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“…Determination of the hardness: The hardness of the polyphosphate material Ca-polyP2 was determined by a ferruled optical fiber-based nanoindenter [21].…”

Section: Methodsmentioning

confidence: 99%

A new polyphosphate calcium material with morphogenetic activity

et al. 2015

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“…Determination of the hardness: The hardness of the polyphosphate material Ca-polyP2 was determined by a ferruled optical fiber-based nanoindenter [21].…”

Section: Methodsmentioning

confidence: 99%

A new polyphosphate calcium material with morphogenetic activity

et al. 2015

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“…For the 1:1 ratio, no image was obtained due to a probable ferrule contamination, in the sample or from sample residues attached to the tip-cantilever. 40 Image analysis obtained in the 3:1 ratio showed nanoparticles with a dry diameter by height of 120 nm ( Figure 1A and B) with a bimodal Gaussian distribution between 69 and 260 nm ( Figure S2). In order to confirm the nanoparticle size (at 3:1 ratio), SEM analyses were also performed and showed particles with uniform shapes ( Figure 1C and D).…”

Section: Morphological Characterization Of Nanoparticlesmentioning

confidence: 99%

Clavanin bacterial sepsis control using a novel methacrylate nanocarrier

Saúde¹,

Ombredane²,

Silva³

et al. 2014

IJN

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Controlling human pathogenic bacteria is a worldwide problem due to increasing bacterial resistance. This has prompted a number of studies investigating peptides isolated from marine animals as a possible alternative for control of human pathogen infections. Clavanins are antimicrobial peptides isolated from the marine tunicate Styela clava , showing 23 amino acid residues in length, cationic properties, and also high bactericidal activity. In spite of clear benefits from the use of peptides, currently 95% of peptide properties have limited pharmaceutical applicability, such as low solubility and short half-life in the circulatory system. Here, nanobiotechnology was used to encapsulate clavanin A in order to develop nanoantibiotics against bacterial sepsis. Clavanin was nanostructured using EUDRAGIT ® L 100-55 and RS 30 D solution (3:1 w:w). Atomic force, scanning electron microscopy and dynamic light scattering showed nanoparticles ranging from 120 to 372 nm in diameter, with a zeta potential of -7.16 mV and a polydispersity index of 0.123. Encapsulation rate of 98% was assessed by reversed-phase chromatography. In vitro bioassays showed that the nanostructured clavanin was partially able to control development of Staphylococcus aureus , Klebsiella pneumoniae , and Pseudomonas aeruginosa . Furthermore, nanostructures did not show hemolytic activity. In vivo sepsis bioassays were performed using C57BL6 mice strain inoculated with a polymicrobial suspension. Assays led to 100% survival rate under sub-lethal sepsis assays and 40% under lethal sepsis assays in the presence of nanoformulated clavanin A until the seventh day of the experiment. Data here reported indicated that nanostructured clavanin A form shows improved antimicrobial activity and has the potential to be used to treat polymicrobial infections.

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“…The fabrication approach used for the designed LOF seismic sensors was adapted from the field of ferrule-top technology. Early demonstrations of this fabrication route 26,27,29 involved the carving of a glass ferrule using a ps-laser ablation tool to obtain cantilever-based structures. Here, we adopt the same approach using more flexible and rapid fabrication steps, as shown schematically in Fig.…”

Section: Numerical Analysismentioning

confidence: 99%

Opto-mechanical lab-on-fibre seismic sensors detected the Norcia earthquake

Pisco

Bruno

Galluzzo

et al. 2018

26th International Conference on Optical Fiber Sensors

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We have designed and developed lab-on-fibre seismic sensors containing a micro-opto-mechanical cavity on the fibre tip. The mechanical cavity is designed as a double cantilever suspended on the fibre end facet and connected to a proof mass to tune its response. Ground acceleration leads to displacement of the cavity length, which in turn can be remotely detected using an interferometric interrogation technique. After the sensors characterization, an experimental validation was conducted at the Italian National Institute of Geophysics and Volcanology (INGV), which is responsible for seismic surveillance over the Italian country. The fabricated sensors have been continuously used for long periods to demonstrate their effectiveness as seismic accelerometer sensors. During the tests, fibre optic seismic accelerometers clearly detected the seismic sequence that culminated in the severe Mw6.5 Norcia earthquake that struck central Italy on October 30, 2016. The seismic data provided by the optical sensors were analysed by specialists at the INGV. The wave traces were compared with stateof-the-art traditional sensors typically incorporated into the INGV seismic networks. The comparison verifies the high fidelity of the optical sensors in seismic wave detection, indicating their suitability for a novel class of seismic sensors to be employed in practical scenarios. Earthquakes occur frequently worldwide. Seismic events with various intensities are continuously revealed by seismic stations located in various parts of the world 1. Most earthquakes cause vibrations that cannot be perceived by humans. However, the release of elastic energy associated with some earthquakes can generate seismic waves with sufficient force to damage buildings or trigger catastrophic collapses 2. During only the past ten years, several devastating earthquakes have occurred 3. Although earthquakes occur worldwide, most are concentrated in high seismic risk zones located at tectonic plate boundaries. Italy, for example, lies at the contact point between tectonic plates, where intense tectonic movements currently induce seismic activity in geographical correspondence with the Apennine Mountains. As a consequence, strong earthquakes frequently strike central Italy (

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Note: Ferrule-top atomic force microscope. II. Imaging in tapping mode and at low temperature

Cited by 17 publications

References 9 publications

A new polyphosphate calcium material with morphogenetic activity

A new polyphosphate calcium material with morphogenetic activity

Clavanin bacterial sepsis control using a novel methacrylate nanocarrier

Opto-mechanical lab-on-fibre seismic sensors detected the Norcia earthquake

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