Note of clarification of data on the association between CYP2E1 RsaI polymorphism and lung cancer risk

Zhai, Wenlong; Feng, Ru; Yang, Haiyan; Wang, Yadong

doi:10.1016/j.ejca.2015.04.029

Cited by 1 publication

(1 citation statement)

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“…[ 24 ] CYP2E1 is a member of the cytochrome P450 superfamily and is involved in the metabolic activation of many carcinogens, such as gastric cancer [ 25 ] and lung cancer. [ 26 ] These PPI network results demonstrated the crucial functional linkages between the DEGs in the pancreatic carcinogenesis.…”

Section: Discussionmentioning

confidence: 84%

Identification of novel therapeutic target genes and pathway in pancreatic cancer by integrative analysis

Cheng²,

Jiang³

et al. 2017

Medicine

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Background:Gene alterations are crucial to the molecular pathogenesis of pancreatic cancer. The present study was designed to identify the potential candidate genes in the pancreatic carcinogenesis.Methods:Gene Expression Omnibus database (GEO) datasets of pancreatic cancer tissue were retrieval and the differentially expressed genes (DEGs) from individual microarray data were merged. Gene Ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, protein–protein interaction (PPI) networks, and gene coexpression analysis were performed.Results:Three GEO datasets, including 74 pancreatic cancer samples and 55 controls samples were selected. A total of 2325 DEGs were identified, including 1383 upregulated and 942 downregulated genes. The GO terms for molecular functions, biological processes, and cellular component were protein binding, small molecule metabolic process, and integral to membrane, respectively. The most significant pathway in KEGG analysis was metabolic pathways. PPI network analysis indicated that the significant hub genes including cytochrome P450, family 2, subfamily E, polypeptide 1 (CYP2E1), mitogen-activated protein kinase 3 (MAPK3), and phospholipase C, gamma 1 (PLCG1). Gene coexpression network analysis identified 4 major modules, and the potassium channel tetramerization domain containing 10 (KCTD10), kin of IRRE like (KIRREL), dipeptidyl-peptidase 10 (DPP10), and unc-80 homolog (UNC80) were the hub gene of each modules, respectively.Conclusion:Our integrative analysis provides a comprehensive view of gene expression patterns associated with the pancreatic carcinogenesis.

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Section: Discussionmentioning

confidence: 84%