We study holographic subregion complexity in a spatially anisotropic field theory, which expresses a confinement-deconfinement phase transition. Its holographic dual is a five-dimensional anisotropic holographic model characterized by a Van der Waals-like phase transition between small and large black holes. We propose a new interpretation from the informational perspective to determine the stable and unstable thermodynamically solutions. According to this proposal, the states which need (more) less information to be specified characterize the (un) stable solutions. We similarly offer an interpretation to determine the stable and unstable solutions based on the resource of a computational machine, such that the solutions are (un) stable if computational resource (decreases) increases with the increase of temperature. We observe that the effect of anisotropy on holographic subregion complexity is decreasing. This decreasing effect can be interpreted by considering a whole closed system consisting of the state and its environment in which the complexity of the mixed state decreases and complexity of the environment increases.