Notes: Flavonols from Scurrula ferruginea Danser (Loranthaceae)

Abstract

Three natural flavonols compounds have been isolated from the ethyl acetate fraction of Scurrula ferruginea Danser (Loranthaceae). Besides quercetin and quercitrin, an unusual flavonol glycoside 4″-O-acetylquercitrin was isolated. Structures were determined using spectroscopic methods including UV, NMR and HRMS-EI. The incidence of 4″-O-acetylquercitrin, not previously reported in the Loranthaceae, is discussed. Cytotoxic evaluation on four human cancer cell lines showed quercetin to be the most active with IC50 of 35 μм on U251 (human glioblastoma cells).

Scurrula ferruginea (Jack) Danser: Therapeutic Applications and Future Opportunities

“…Despite its application as traditional medicine, there was a limited study investigated its application directly to a specific disease. Previous studies reported the potent therapeutic applications of S. ferruginea on its antioxidant activity ( Marvibaigi et al, 2014), blood pressure reduction activity (Ameer et al, 2009), and cytotoxic activity (Lohézic- Le Dévéhat et al, 2002b). However, the details about bioactive compounds related to those therapeutic effects were not mentioned in detailed from the studies.…”

“…The study on the potential of S. ferruginea mistletoe to inhibit cancer cell has been done by F. Lohézic- Le Dévéhat, S. Tomasi, D. Fontanel, and J. Boustie (2002a) One of the assorted mistletoes that have been common used in herbal medicine is the family of Loranthaceae. Even though there is a slightly published paper of S. ferruginea supporting a lowering activity of blood pressure (Ameer et al 2009;Marvibaigi et al 2016), within other Loranthaceae family which related species have been many reported for their activity of antihypertensive.…”

“…Thus, further analysis on specific bioactive compounds from S.ferruginea that can directly use to treat a disease need to be studied. There was a study by Lohézic- Le Dévéhat et al (2002a) reported bioactive compounds of S.ferruginea which responsible to cytotoxic activity from the group of flavonoids including quercetin, quercitrin, dan 4-O-acetylquercitrin. They performed that quercetin contained in S.ferruginea is an active antioxidant which could be further developed on its anticancer activity.…”

Characteristic variation in pigment composition, photosynthetic carbon assimilation and phytonutrients content of Dendrophthoe falcata, a hemiparasite growing on host trees of saline and non-saline environments

“…According to Devehat et al [27], the peaks in the IR spectra (3350, 2926, and 1634) obtained from the leaf samples of D. falcata revealed the presence of quercitrin, which is reported as a taxonomic marker of the Loranthaceae family. The reported chemical examination of D. falcata growing on Terminalia tmentosa has revealed the presence of gallic, ellagic, and chebulinic acids, and quercetin [29].…”

“…The LC 50 values for the radical scavenging activity of D. falcata from R. mucronata was 47 μg/mL and from A. lebbeck-41 µg/mL (Table 3). Önay Uçar et al [26] hydrogen donation at the C 3 position that enhanced the antioxidant activity [27].…”