Notes on the genus Paramignya : Phytochemistry and biological activity

Son, Ninh The

doi:10.1016/j.bfopcu.2017.12.001

Cited by 11 publications

(12 citation statements)

References 19 publications

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“…Five alkyl triphenylphosphonium-conjugated ostruthins (1)(2)(3)(4)(5) were, for the first time, synthesized and investigated as potential cytotoxic agents. These derivatives were evaluated for cytotoxic activity against human PANC-1 pancreatic, HeLa cervical, and HepG2 liver cancer cell lines.…”

Section: Resultsmentioning

confidence: 99%

“…The optimal molar equivalent of 1.5 for carbodiimides was determined experimentally. Applying all optimal conditions, five alkyl triphenylphosphonium ostruthin derivatives (1)(2)(3)(4)(5) were successfully synthesized with the yields ranging from 27.5 to 38.6 %. All products were identified by the 1 H NMR data.…”

Section: Synthesismentioning

confidence: 99%

“…Burkill (Rutaceae) is a woody shrub, which is an endemic species in South Vietnam. [1] The MeOHsoluble extract of P. trimera roots showed cytotoxicity against many human cancer cell lines such as MIA PaCa-2, BxPC-3, CFPAC-1 (pancreas), HT-29 (colon), A2780 (ovarian), NCIÀ H460 (lung), A-431 (skin), DU145 (prostate), BE(2)-C (neuroblastoma), MCF-7 (breast), and U-87 MG, SJ-GBM2 (glioblastoma). [2] Ostruthin, 6-geranyl-7-hydroxycoumarin, is the main constituent in the roots of P. trimera.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of Alkyl Triphenylphosphonium Ostruthin Derivatives as Potential Cytotoxic Candidates

Dang

Dao

et al. 2020

ChemistrySelect

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Ostruthin, isolated from Paramignya trimera, was used as a scaffold to design its alkyl triphenylphosphonium derivatives. With the optimal reaction conditions in hand, five alkyl triphenylphosphonium ostruthin derivatives (1–5) were synthesized. Ostruthin and its derivatives were tested for cytotoxicity against human PANC‐1 pancreatic, Hela cervical, and HepG2 liver cancer cell lines. Ostruthin and its hexyl and heptyl triphenylphosphonium derivatives (4 and 5) showed strong preferential cytotoxicity against PANC‐1 cells with the PC50 values of 10.3 and 14.4 μM, respectively. In addition, compounds 4 and 5 also exhibited potent cytotoxicity towards HeLa cells with the IC50 values of 24.8 and 18.5 μM, respectively. The hexyl triphenylphosphonium group in 4 was found to slightly enhance cytotoxicity against HepG2 cells. Further, the morphological changes and the live‐cell imaging result suggested the anticancer potential against HeLa cells of the synthesized ostruthin derivative 5.

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Section: Resultsmentioning

confidence: 99%

Section: Synthesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis of Alkyl Triphenylphosphonium Ostruthin Derivatives as Potential Cytotoxic Candidates

Dang

Dao

et al. 2020

ChemistrySelect

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“…Recently, various potential bioactivities, i.e., antioxidant, antibacterial, and anticancer activities and hepatoprotective property, were reported from the plant's roots, leaves, and stems. Many compounds that belong to coumarins, acridone alkaloids, phenols, flavonoids, and chromenes classes have been isolated from these tissues (Table 1S, Supplementary Materials) [9][10][11][12][13][14][15][16][17][18][19]. Furthermore, being a perennial woody plant, the exploitation of this plant from other tissues, i.e., fruits, instead of roots, leaves, or stems, may provide a chance to conserve this valuable medicinal plant.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Potential Antibacterial Activity of Defatted and Nondefatted Methanolic Extracts of Xao Tam Phan (Paramignya trimera (Oliv.) Guillaum) Peels against Multidrug-Resistant Bacteria

Thi

Nguyen

et al. 2021

Scientifica

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Xao tam phan (Paramignya trimera (Oliv.) Guillaum) is a traditional herbal medicine in Vietnam. Previous investigations reported mainly compounds and bioactivities of roots, stems, and leaves while there is limited information about those of fruits. This study aims to reveal the difference in the chemical profile of defatted peel (DP) and nondefatted peel (NDP) methanolic extracts of P. trimera using colorimetric reactions and liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) analysis. We also showed the potential antibacterial activity of two extracts against clinically isolated bacteria strains including P. aeruginosa, Salmonella sp., and S. aureus with the MIC values < 100 μg/mL. This preliminary result proves the traditional usage of this herbal medicine and can be helpful for further investigation on the isolation and identification of the new compounds in P. trimera peels.

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“…The Paramignya species were employed in traditional medication treating cancer, hepatitis, diabetes and nose infections. Particularly, their extracted-active compounds exhibited anti-tumour, antioxidant, and anti-inflammatory effects [10]. However, to date, there have not been many attempts on investigating the chemical compositions and biological activities of essential oils extracted from these species.…”

Section: Introductionmentioning

confidence: 99%

Biological Activities of Essential Oils from Leaves of Paramignya trimera (Oliv.) Guillaum and Limnocitrus littoralis (Miq.) Swingle

Doan

et al. 2020

Antibiotics

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The present study aimed to determine the bioactivities of essential oils extracted from the leaves of Paramignya trimera and Limnocitrus littoralis, including cytotoxicity, antiviral, antibacterial, antimycotic, and antitrichomonas effects. Herein, it was indicated that P. trimera and L. littoralis oils showed no cytotoxicity on normal cells, namely MT-4, BHK-21, MDBK, and Vero-76. P. trimera oil (i) exhibited the strongest inhibition against Staphylococcus aureus with MIC and MLC values of 2% (v/v); (ii) showed MIC and MLC values of 8% (v/v) in Candida parapsilosis; and (iii) in the remaining strains, showed MIC and MLC values greater than or equal to 16% (v/v). On the other hand, L. littoralis oil (i) displayed the strongest inhibition against Candida tropicalis and Candida parapsilosis with 2% (v/v) of MIC and MLC; and (ii) in the remaining strains, possessed MIC and MLC greater than or equal to 16% (v/v). In addition, antitrichomonas activities of the oils were undertaken, showing IC50, IC90, MLC values, respectively, at 0.016%, 0.03%, and 0.06% (v/v) from P. trimera, and 0.03%, 0.06%, 0.12% (v/v) from L. littoralis, after 48 h of incubation. The oils were completely ineffective against ssRNA+ (HIV-1, YFV, BVDV, Sb-1, CV-B4), ssRNA- (RSV, VSV), dsRNA (Reo-1), and dsDNA (HSV-1, VV) viruses. This is the first report describing the cytotoxicity, antiviral, antibacterial, antimycotic, and antitrichomonas activities of the essential oils of P. trimera and L. littoralis.

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Notes on the genus Paramignya : Phytochemistry and biological activity

Cited by 11 publications

References 19 publications

Synthesis of Alkyl Triphenylphosphonium Ostruthin Derivatives as Potential Cytotoxic Candidates

Synthesis of Alkyl Triphenylphosphonium Ostruthin Derivatives as Potential Cytotoxic Candidates

Phytochemical Screening and Potential Antibacterial Activity of Defatted and Nondefatted Methanolic Extracts of Xao Tam Phan (Paramignya trimera (Oliv.) Guillaum) Peels against Multidrug-Resistant Bacteria

Biological Activities of Essential Oils from Leaves of Paramignya trimera (Oliv.) Guillaum and Limnocitrus littoralis (Miq.) Swingle

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