Notes on the Use of “Librium” in the Treatment of Alcoholism

Speight, Peter

doi:10.5694/j.1326-5377.1960.tb68905.x

Cited by 7 publications

(3 citation statements)

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“…In a series of 90 patients with various disorders, he noted reactions of sleepiness, depression, loss of libido, ataxia and dizziness in 11, necessitating discontinuance of the drug in 5. Speight (9) treated two classes of alcoholic patients—the tension type and the neurotic type—and found that they were benefited by Librium therapy. However, he did not state the number of patients or the duration of therapy.…”

Section: Discussionmentioning

confidence: 99%

The Use of Chlordiazepoxide (Librium) in the Alcoholic Patient: A Clinical Study of Forty Cases

Chesrow¹,

Kaplitz²,

Levine³

et al. 1962

J American Geriatrics Society

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Section: Discussionmentioning

confidence: 99%

The Use of Chlordiazepoxide (Librium) in the Alcoholic Patient: A Clinical Study of Forty Cases

Chesrow¹,

Kaplitz²,

Levine³

et al. 1962

J American Geriatrics Society

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“…At baseline and at each blood sampling (up to 8 hours), the following 1OO-mm analog scales of subjective effects of benzodiazepine drugs in abstinent alcoholic men were administered: 1) Drug Feeling Scale, 2) Sedation Scale, 3) Drug Liking Scale, 4) Alcohol Craving Scale, 5) the Tufts ARCI-MBG Scale, and 6) Drug High Scale (i.e., "This is a drug someone could really get high on"). These scales are available from the authors upon request.…”

Section: Methodsmentioning

confidence: 99%

Alterations in Pharmacodynamics of Anxiolytics in Abstinent Alcoholic Men: Subjective Responses, Abuse Liability, and Electroencephalographic Effects of Alprazolam, Diazepam, and Buspirone

Ciraulo

Barnhill

Ciraulo

et al. 1997

The Journal of Clinical Pharma

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Subjective responses, including those associated with abuse liability and changes in frontal electroencephalographic activity, were assessed in abstinent alcoholic men and control subjects after administration of alprazolam, diazepam, buspirone, and placebo. Plasma concentrations of alprazolam, diazepam, and desmethyldiazepam also were determined. Abuse liability scales were elevated for alcoholic participants above control levels after alprazolam and diazepam. Areas under the concentration-time curve differed only for desmethyldiazepam, which was lower for the alcoholic participants. Compared with control subjects, alcoholic participants had greater declines in the absolute power of the alpha band after diazepam challenge. Alcoholic participants, unlike control subjects, had areas under the effect-time curve for alpha and theta bands that were lower after administration of alprazolam or diazepam than they were after receiving placebo. These results suggest that alprazolam and diazepam are more likely to be abused by alcoholic men than by nonalcoholic men and that alcoholic men have enhanced sensitivity to the effects of benzodiazepines on alpha and theta activity.

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“…The self‐medication hypothesis 188 suggests that BZDs could be used as a substitute for alcohol in the treatment of anxiety and consequently might reduce the rates of alcohol abuse or dependence. This possibility was considered by some soon after BZDs were introduced 189,190 . The largest study examining this looked at 123 detoxified outpatient alcoholics 191 .…”

Section: Do Benzodiazepines Decrease the Risk Of Alcohol Relapse?mentioning

confidence: 99%

Assessing the Risks and Benefits of Benzodiazepines for Anxiety Disorders in Patients with a History of Substance Abuse or Dependence

Posternak

Mueller

2001

American J Addict

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In this article, the authors reevaluate the traditional position that benzodiazepines should be avoided in anxiety disorder patients with a history of substance abuse or dependence. The efficacy of benzodiazepines in each of the anxiety disorders is reviewed, as are their side effects and toxicity. The definitions of benzodiazepine abuse and dependence are discussed, and relevant animal, experimental, and clinical data are reviewed and analyzed. A manual and computerized (MEDLINE) search was performed from 1966 to the present to examine the English-language literature published on benzodiazepines, substance abuse, and each of the anxiety disorders listed in DSM-IV. The authors found that benzodiazepines have demonstrated efficacy in generalized anxiety disorder, panic disorder, and agoraphobia; they are promising agents in the treatment of social phobia and alcohol-induced anxiety disorders. They are generally well tolerated. There is much ambiguity over appropriate definitions for benzodiazepine abuse and dependence: although most benzodiazepine abusers concurrently abuse other substances, there is little evidence to indicate that a history of substance abuse is a major risk factor for future benzodiazepine abuse or dependence. Furthermore, benzodiazepines do not appear to induce relapse of substance abuse in these patients. The authors conclude that the position that benzodiazepines are contraindicated in former substance abusers appears to lack empirical justification. Benzodiazepines may be indicated in certain patients with anxiety disorders and a history of substance abuse or dependence.

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Notes on the Use of “Librium” in the Treatment of Alcoholism

Cited by 7 publications

References 0 publications

The Use of Chlordiazepoxide (Librium) in the Alcoholic Patient: A Clinical Study of Forty Cases

The Use of Chlordiazepoxide (Librium) in the Alcoholic Patient: A Clinical Study of Forty Cases

Alterations in Pharmacodynamics of Anxiolytics in Abstinent Alcoholic Men: Subjective Responses, Abuse Liability, and Electroencephalographic Effects of Alprazolam, Diazepam, and Buspirone

Assessing the Risks and Benefits of Benzodiazepines for Anxiety Disorders in Patients with a History of Substance Abuse or Dependence

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