2010
DOI: 10.1038/nm1010-1063
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Nothing to sneeze at

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Cited by 10 publications
(9 citation statements)
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“…The discovery of fragment 4 and 18 offer new opportunities to develop a dual H 1 R-H 4 R ligand with synergistic anti-inflammatory properties. 60 For example, the pyrazolo methyl group of fragment 4 could be used as a handle to grow the ligand towards the extracellular region of the binding site between TM5 and TM6 (Fig. 2C) to fine tune H 1 R and H 4 R affinity by introducing groups matching previously identified interaction hot spots for these receptors (e.g., K191 5..39 in H 1 R, and L175 5.39 in H 4 R).…”
Section: Resultsmentioning
confidence: 99%
“…The discovery of fragment 4 and 18 offer new opportunities to develop a dual H 1 R-H 4 R ligand with synergistic anti-inflammatory properties. 60 For example, the pyrazolo methyl group of fragment 4 could be used as a handle to grow the ligand towards the extracellular region of the binding site between TM5 and TM6 (Fig. 2C) to fine tune H 1 R and H 4 R affinity by introducing groups matching previously identified interaction hot spots for these receptors (e.g., K191 5..39 in H 1 R, and L175 5.39 in H 4 R).…”
Section: Resultsmentioning
confidence: 99%
“…Many cellular metabolites influence immune reactivity (eg, retinoic acid), and one factor that is receiving more attention as an immunomodulator is histamine (2-[4-imidazolyl]-ethylamine). 1,2 This short-acting endogenous amine, which is widely distributed throughout the body, is synthesized by histidine decarboxylase (HDC), which decarboxylates the semiessential amino acid L-histidine. Originally discovered at the beginning of the 20th century, histamine was first chemically synthesized by Windaus and Vogt in 1907.…”
mentioning
confidence: 99%
“…Histamine [2‐(4‐imidazolyl)‐ethylamine] is a short‐acting endogenous amine, which is widely distributed throughout the body . Histamine is synthesized by the enzyme histidine decarboxylase (HDC), which decarboxylates the semi‐essential amino acid l ‐histidine.…”
mentioning
confidence: 99%