Notice of Removal: Rapid short-pulse (RaSP) sequences improve the distribution of drug delivery to the brain in vivo

Morse, Sophie V.; Pouliopoulos, Antonios N.; Chan, Tiffany G.; Lin, Julien; Copping, Matthew J.; Long, Nicholas J.; Choi, James J.

doi:10.1109/ultsym.2017.8092158

Cited by 1 publication

(1 citation statement)

References 33 publications

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“…Recently, Moncion et al (2018) studied the possibility to use focused US for a spatiotemporally controlled release of two different growth factors from an acoustically responsive scaffold, in order to help angiogenesis and osteogenesis. Morse et al (2017) studied the effect of focused US on microbubbles in order to locally and noninvasively open the blood-brain barrier. They evaluated the ability of a rapid short-pulse sequence to improve the in vivo performance and safety of ultrasound-mediated drug delivery to the brain.…”

Section: Introductionmentioning

confidence: 99%

Pulsatile Drug Delivery System Triggered by Acoustic Radiation Force

Ciancia

Cafarelli

Zahoranová

et al. 2020

Front. Bioeng. Biotechnol.

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Since biological systems exhibit a circadian rhythm (24-hour cycle), they are susceptible to the timing of drug administration. Indeed, several disorders require a therapy that synchronizes with the onset of symptoms. A targeted therapy with spatially and temporally precise controlled drug release can guarantee a considerable gain in terms of efficacy and safety of the treatment compared to traditional pharmacological methods, especially for chronotherapeutic disorders. This paper presents a proof of concept of an innovative pulsatile drug delivery system remotely triggered by the acoustic radiation force of ultrasound. The device consists of a case, in which a drug-loaded gel can be embedded, and a sliding top that can be moved on demand by the application of an acoustic stimulus, thus enabling drug release. Results demonstrate for the first time that ultrasound acoustic radiation force (up to 0.1 N) can be used for an efficient pulsatile drug delivery (up to 20 µg of drug released for each shot).

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Section: Introductionmentioning

confidence: 99%