Notice of Retraction: Protein Phosphorylation of NRF1 Is Influenced by MCRS2

Abstract

Chien-Fu Huang and Young-Sun Lin contribute equally to this paper.A. Abstract-Nrf1 [p45 nuclear factor-erythroid 2 (p45 NF-E2)-related factor 1], a member of the CNCbZIP (CNC basic region leucine zipper) family, is known to be a transcriptional activator by dimerization with its distinct partners, such as Maf, FosB, c-Jun, JunD, etc. The transcriptional roles of CNC-bZIP family are demonstrated to be involved in globin gene expression as well as the antioxidant response. MCRS2, a protein with transforming, nucleolar sequestration, ribosomal gene regulation, as well as telomerase inhibition activities, was identified as a novel interacting protein of Nrf1. In this study, we find that ERK1/2 phosphorylates Nrf1 during the interaction between Nrf1 and MCRS2. The phosphorylation of Nrf1 is induced by MCRS2 among the interactions between MCRS2 and Nrf1.