Nourishing the Cognition with Millets: A Comprehensive Review of Their Nutritional Impact and Potential as Cognitive Enhancers

Premachandran, Krishnamanikumar; Wilson Alphonse, Carlton Ranjith; Soundharapandiyan, Nandhagopal

doi:10.1002/mnfr.202300450

Cited by 5 publications

(1 citation statement)

References 106 publications

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“…Complex mixtures of polyphenols in sorghum grain extracts, such as 3-deoxyanthocyanidins (DXA) have the potential to inhibit neurotoxic aggregation to prevent and treat Alzheimer’s disease ( 116 ). Millets have also demonstrated neuroprotective effects in Parkinson’s disease and other cognitive disorders ( 117 ).…”

Section: Other Diseasesmentioning

confidence: 99%

The nutrition and therapeutic potential of millets: an updated narrative review

Jacob,

Krishnan,

Antony

et al. 2024

Front. Nutr.

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Millets are ancient small grains grown in arid and semiarid regions of the world. They are staple food for many people in Asia and Africa. They are abundant sources of minerals and vitamins, giving them the name Nutricereals. Moreover, millets contain valuable phytochemicals that impart therapeutic properties for various disorders and diseases, thus giving them nutraceutical value. A wide array of biochemical compounds are present in the plant parts as well as the grains. In the oldest texts of medicine in India and China, millets are mentioned for use for their medicinal value. There has been expanding interest and emerging facts about millets and their therapeutic uses. Ample evidence shows that consumption of millets amounts to correction of life style and metabolic disorders. Therapeutic properties of millets can be viewed in two ways, supplementary nutrition through minerals and vitamins, and therapeutic value through the presence of phytochemicals and specialty compounds that include flavonoids, phenolics, anthocyanidins and others that have antioxidant potential. Millets are gluten free, have low glycemic index and the phytochemicals aid in correction of lifestyle disorders and prevention of ailments like carcinogenesis. Supplementary benefits include treatment of anemia and calcium deficiency especially for pregnant women and young children. With the improvements in analytical methods for detection of various compounds, it is possible to identify the compound-specific genotypes in millets that can cater to the pharmacy industry. End-use specific genotypes can be bred to meet the demand. Millets being climate resilient, can contribute to a healthier life and better world through economic usage of natural resources.

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Section: Other Diseasesmentioning

confidence: 99%

The nutrition and therapeutic potential of millets: an updated narrative review

Jacob,

Krishnan,

Antony

et al. 2024

Front. Nutr.

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Millet‐Based Food Adoption for Environmental Sustainability and Nutritional Security

Mallick,

Rajnish,

Mondal

et al. 2024

Ecosystem Management

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Lactobacillus acidophilus 6074 Fermented Jujube Juice Ameliorated DSS‐induced Colitis via Repairing Intestinal Barrier, Modulating Inflammatory Factors, and Gut Microbiota

Li,

Fan,

Yang

et al. 2024

Molecular Nutrition Food Res

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Lactobacillus acidophilus L. acidophilus Lactobacillus, Bifidobacterium, and Akkermansia, This study aimed to explore the ameliorative effects and underlying mechanisms of oral administration Lactobacillus acidophilus 6074 fermented jujube juice (LAFJ) on dextran sulfate sodium (DSS)‐induced colitis in mice. In this study, jujube juice was used as a substrate and fermented by L. acidophilus 6074 to investigate its effects on gut microbiota, intestinal barrier function, oxidative stress, inflammatory factors, and short‐chain fatty acids (SCFAs) in mice with colitis and to reveal its potential mechanism for alleviating colitis. The results demonstrated that fermentation caused significant changes in the nutrients and nonnutrients of jujube juice, mainly in organic acids (malic acid, lactic acid, citric acid, and succinic acid) and free amino acids (Thr, Met, Ser, Ile, and Lys). High‐dose LAFJ (20 mL/kg/day) significantly reduced the disease activity index (DAI), improved histopathological morphology, and increased colon length in colitis mice. LAFJ alleviated colon damage and preserved the integrity of the colonic mucosal barrier by promoting the expression of colonic tight junction proteins occludin, claudin‐1, and zonula occluden‐1 (ZO‐1). Furthermore, LAFJ inhibited the production of proinflammatory factors and attenuated oxidative stress. Gut microbiota of mice revealed that LAFJ increased beneficial bacteria such as Lactobacillus, Bifidobacterium, and Akkermansia, promoted the production of SCFAs, and inhibited the growth of harmful microorganisms. Overall, LAFJ could reshape and restore gut microbiota imbalance caused by intestinal inflammation and alleviate the development of colitis, which may become a novel dietary intervention.

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Nourishing the Cognition with Millets: A Comprehensive Review of Their Nutritional Impact and Potential as Cognitive Enhancers

Cited by 5 publications

References 106 publications

The nutrition and therapeutic potential of millets: an updated narrative review

The nutrition and therapeutic potential of millets: an updated narrative review

Millet‐Based Food Adoption for Environmental Sustainability and Nutritional Security

Lactobacillus acidophilus 6074 Fermented Jujube Juice Ameliorated DSS‐induced Colitis via Repairing Intestinal Barrier, Modulating Inflammatory Factors, and Gut Microbiota

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