Nouvelle perspective de traitement dans le cancer bronchique non à petites cellules (CBNPC). Place de l’afatinib : un inhibiteur oral et irréversible de la famille ErbB

Wislez, Marie; Malka, David; Bennouna, Jaafar; Mortier, Laurent; Bensadoun, René-Jean; Sicard, Jérôme; Dielenseger, Pascale; Rey, Jean‐Baptiste; Moro-Sibilot, Denis; Scotté, Florian

doi:10.1684/bdc.2014.1986

Cited by 5 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to (Fama, 1970), in an efficient market, prices will reflect available information and as implication prices will react immediately without any bias towards new information. Fama (1970) divides market efficiency into three forms, market efficiency in the form of weak, semistrong, and strong forms. Weak form markets are characterized by stock prices or securities that fully reflect past information.…”

Section: Literature Review 21 Efficient Market Hypothesis and Agencymentioning

confidence: 99%

The Effect of Firm Value and Financial Performance on Earnings Management in Sharia Issuers: Evidence From the Indonesia Stock Exchange

Muslim¹

2020

JBFEM

View full text Add to dashboard Cite

Earnings management is still an interesting focus of research from year to year. Research does not only focus on conventionally based entities but also moves to Sharia entities. This study aims to investigate the effect of firm value and financial performance on earning management. From the 20 sharia issuers that were successfully analyzed as samples, we found that, in general, there is no strong evidence that Islamic issuers practice earnings management, this can be seen from the positive average discretionary accruals. Referring to the discussion of the influence of firm value as measured by Tobin’s Q on the practice of earnings management, it was concluded that firm value had a significant effect on earnings management practices. This research has two contributions. Firstly this research is expected to contribute to market-based accounting research. Secondly, this study provides evidence of earnings management practices for Islamic entities.

show abstract

Section: Literature Review 21 Efficient Market Hypothesis and Agencymentioning

confidence: 99%

The Effect of Firm Value and Financial Performance on Earnings Management in Sharia Issuers: Evidence From the Indonesia Stock Exchange

Muslim¹

2020

JBFEM

View full text Add to dashboard Cite

show abstract

“…Afatinib is new generation TKI, and is an irreversible inhibitor of the tyrosine kinase activity of members of the epidermal growth factor receptor family (ErbB) including EGFR, HER2 and ErbB4 [ 12 , 18 , 22 , 23 ]. Afatinib covalently binds to cysteine 797 of EGFR and cysteines 805 and 803 in HER2 and ErbB4, respectively.…”

Section: Introductionmentioning

confidence: 99%

Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A

et al. 2014

View full text Add to dashboard Cite

Afatinib has anti-tumor effect in non-small cell lung carcinoma (NSCLC) with epidermal growth factor receptor (EGFR) mutation. We found afatinib can also induce apoptosis in NSCLC cells without EGFR mutation through CIP2A pathway. Four NSCLC cell lines (H358 H441 H460 and A549) were treated with afatinib to determine their sensitivity to afatinib-induced cell death and apoptosis. The effects of CIP2A on afatinib-induced apoptosis were confirmed by overexpression and knockdown of CIP2A expression in the sensitive and resistant cells, respectively. Reduction of Elk-1 binding to the CIP2A promoter and suppression of CIP2A transcription were analyzed. In vivo efficacy of afatinib against H358 and H460 xenografts tumors were also determined in nude mice. Afatinib induced significant cell death and apoptosis in H358 and H441 cells, but not in H460 or A549 cells. The apoptotic effect of afatinib in sensitive cells was associated with downregulation of CIP2A, promotion of PP2A activity and decrease in AKT phosphorylation. Afatinib suppressed CIP2A at the gene transcription level by reducing the promoter binding activity of Elk-1. Clinical samples showed that higher CIP2A expression predicted a poor prognosis and Elk-1 and CIP2A expressions were highly correlated. In conclusion, afatinib induces apoptosis in NSCLC without EGFR mutations through Elk-1/CIP2A/PP2A/AKT pathway.

show abstract

“…Since low degree of differentiation and absence of lymphatic metastasis benefit post-chemotherapy survival and reduce adverse reactions, TNM staging is indispensable before treatment. 23 Furthermore; positive EGFR expression indirectly reflects the controlling of tumor pathological changes by drugs, the changes of which may predict the therapeutic effects of chemotherapy and post-treatment adverse reactions. The currently available EGFR-targeted drugs, including EGFR-tyrosine kinase inhibitors and monoclonal antibodies, can augment the activities of corresponding inhibitors and the susceptibility to gefitinib.…”

Section: Discussionmentioning

confidence: 99%

Correlation between expression of epidermal growth factor receptor and adverse reactions after chemotherapy of advanced non-small-cell lung cancer

et al. 2015

View full text Add to dashboard Cite

Objective:To analyze the correlation between expression of epidermal growth factor receptor (EGFR) and adverse reactions after chemotherapy of advanced non-small-cell lung cancer (NSCLC).Methods:A total of 120 NSCLC patients who were treated in our hospital from August 2009 to September 2011 were selected as an observation group, and another 120 healthy subjects were selected as a control group. EGFR expressions in both groups were detected. The observation group was subjected to combination chemotherapy, and their shorter- and long-term prognostic outcomes, adverse reactions and mortality were recorded. Meanwhile, correlation analysis was performed.Results:The observation group had significantly higher percentage and positive rate in EGFR expression than those of the control group (P<0.05). With increasing stage and lymphatic metastasis, the positive expression rate of EGFR rose significantly (P<0.05). In the observation group, the response rate of treatment was 62.5%, and the incidence rate of adverse reactions after chemotherapy was 28.3% (34/120). The 1-, 2- and 3-year survival rates were 38.3%, 15.0% and 10.0% respectively. Multiple Logistic regression analysis showed that TNM stage, lymphatic metastasis and positive EGFR expression were the main independent risk factors for post-chemotherapy adverse reactions (P<0.05).Conclusion:Advanced NSCLC was commonly accompanied by high EGFR expression. Although chemotherapy was able to improve the prognosis and survival rate, adverse reactions were also induced, being associated with the pathological characteristics and EGFR expressions of patients.

show abstract

Nouvelle perspective de traitement dans le cancer bronchique non à petites cellules (CBNPC). Place de l’afatinib : un inhibiteur oral et irréversible de la famille ErbB

Cited by 5 publications

References 15 publications

The Effect of Firm Value and Financial Performance on Earnings Management in Sharia Issuers: Evidence From the Indonesia Stock Exchange

The Effect of Firm Value and Financial Performance on Earnings Management in Sharia Issuers: Evidence From the Indonesia Stock Exchange

Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A

Correlation between expression of epidermal growth factor receptor and adverse reactions after chemotherapy of advanced non-small-cell lung cancer

Contact Info

Product

Resources

About