Nouvelles drogues de synthèse (NDS) et dépistage urinaire : une bonne connaissance des réactifs s’impose

Severe serotoninergic syndrome after ingestion of α-methyltryptamine

“…It can be noted that Boland et al described also a positive result for their post-mortem case both in urine and gastric content with amphetamine EMIT Syva ® test [8]. Elsewhere, Swortwood et al described a high range of AMT crossreactivities (no response to 116%) among their 16 tested ELISA serum immunoassays with positive cut-off at either 3 piperazines and 7 other products), mainly amphetaminerelated chemical structures gave positive results [22]. These results suggest that efficient detection of new designer drugs cannot be performed using immunoanalysis and a chromatographic process either by LC-DAD or better by LC-MS/MS should be carried out.…”