Nouvelles stratégies pour la conception de molécules antivirales

Castel, Guillaume; Tordo, Noël

doi:10.1016/s1773-035x(09)70313-2

Cited by 1 publication

(1 citation statement)

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“…The fungal secondary metabolite brefeldin-A (BFA) (1), also known as ascotoxin, cyano, decumbin, and lunatin, belongs to the 13-carbon lactone class and was first isolated by Singleton in 1958 from Penicillium decumbens. [59,60] BFA is a compound with several biological activities, including antitumor, antibacteri-al, and antiviral. [61 -63] It is synthesized by various endophytic fungi such as Penicillium brefeldianum (Eupenicellium brefeldianum), Penicillium cyaneum, and Cladosporium sp.…”

Section: Secondary Metabolites Of Endophytic Fungi With Antiviral Act...mentioning

confidence: 99%

Endophytic Fungi as a Source of Antiviral Compounds – A Review

Lacerda

Polônio

Golias

2022

Chemistry & Biodiversity

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Endophytic fungi are a rich source of secondary metabolites. The interactions between endophytes and their hosts lead to the production of several bioactive substances grouped into different classes, each having a wide variety of effects against various pathogens. The metabolites obtained from these organisms include steroids, alkaloids, phenols, isocoumarins, xanthones, quinones, and terpenoids, among others. These substances are known to have antibiotic, antiparasitic, antifungal, and antiviral effects. This review summarizes secondary metabolites with antiviral effects produced by endophytic fungi and highlights the importance of research in developing novel antiviral substances. We demonstrate that endophytic fungi are a rich source of secondary metabolites that combat pathologies caused by viruses. Optimizing practical and biotechnological screening tools for the research of these metabolites will provide promising drugs to combat these infections.

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Section: Secondary Metabolites Of Endophytic Fungi With Antiviral Act...mentioning

confidence: 99%