NovaSil clay does not affect the concentrations of vitamins A and E and nutrient minerals in serum samples from Ghanaians at high risk for aflatoxicosis

Afriyie-Gyawu, Evans; Wang, Z.; Ankrah, Nii‐Ayi; Liu, Xu; Johnson, Natalie M.; Tang, Lili; Guan, Hongxia; Huebner, Henry J.; Jolly, Pauline E.; Ellis, William O.; Taylor, Robert J.; Brattin, Bryan L.; Ofori‐Adjei, David; Williams, Jonathan; Wang, Jiasheng; Phillips, Timothy D.

doi:10.1080/02652030701854758

Cited by 39 publications

(22 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For nutrient and nonnutrient mineral analysis in milk, 10-mL aliquots from the first treatment period were analyzed by the Veterinary Integrated Biosciences Metals Analysis Laboratory, College of Veterinary Medicine, Texas A&M University (College Station) using atomic absorption and inductively coupled plasma mass spectroscopy (ICP-MS; Afriyie-Gyawu et al, 2008). The metals that were analyzed in milk include Ca, K, Mg, Na, P, S, Ag, Al, As, B, Ba, Be, Cd, Co, Cr, Cu, Fe, Hg, Li, Mn, Mo, Ni, Pb, Sb, Se, Sr, Ti, U, V, and Zn.…”

Section: Sampling and Data Collectionmentioning

confidence: 99%

Effects of calcium montmorillonite clay and aflatoxin exposure on dry matter intake, milk production, and milk composition

Maki

Thomas

Elmore

et al. 2016

Journal of Dairy Science

Self Cite

View full text Add to dashboard Cite

Fifteen primiparous crossbred dairy cows that were 114±14d in milk and weighed 533±56kg were used in a replicated 5×5 Latin square to test the efficacy of a calcium montmorillonite clay, NovaSil Plus (NSP; BASF Corp., Ludwigshaven, Germany), for the reduction of aflatoxin (AF) metabolite (AFM1) in milk and the effect of NSP on milk composition. Cows were housed in a freestall barn, fed once a day and milked twice a day. The experiment consisted of five 14-d periods: d 1 through 7 were considered for data collection, and d 8 through 14 were considered a wash-out phase. In each period, cows were randomly assigned to 1 of 5 dietary treatments: (1) control (CON), consisting of a basal total mixed ration (TMR); (2) high-dose NSP diet (NSP-1%), consisting of TMR plus 230 g of NSP; (3) aflatoxin diet (AFD), consisting of the TMR plus AF challenge; (4) low-dose NSP with AF (NSP-0.5%+AFD), composed of TMR plus 115 g of NSP and AF challenge; and (5) high-dose NSP with AF (NSP-1%+AFD), consisting of TMR plus 230 g of NSP and AF challenge. The AF challenge consisted of top dressing a daily dose of 100 µg/kg estimated dry matter intake (DMI); similarly, NSP was fed at 1.0 or 0.5% of estimated DMI. Milk yield and DMI were similar across treatments averaging 21.1±1.33 kg/d and 19.7±0.56 kg/d, respectively. Concentration of milk fat, protein, and lactose were similar across treatments with averages of 4.91±0.20%, 3.85±0.10%, and 4.70±0.06%, respectively. Concentration of vitamin A averaged 0.28±0.03 µg/mL and riboflavin concentration averaged 1.57±0.13 µg/mL across treatments. The concentration of minerals in milk were similar for all treatments. Cows fed CON and NSP-1% yielded the lowest concentration of AFM1 in milk with 0.03 and 0.01±0.06 µg/L. Addition of NSP reduced milk AFM1 from 1.10±0.06 µg/L with the AF diet to 0.58 and 0.32±0.06 µg/L with the NSP-0.5%+AF and NSP-1%+AF diets, respectively. Excretion of AFM1 was reduced by NSP; mean values were 24.38, 11.86, 7.38, 0.64, and 0.23, ± 1.71 µg/d, for AFD, NSP-0.5%+AFD, NSP-1%+AFD, NSP-1%, and CON, respectively. More specifically, 1.07±0.08% of the daily AF intake was transferred to the milk of cows consuming the AFD, whereas the AF transfer rates in milk from cows that consumed the NSP-0.5%+AFD and NSP-1%+AFD were 0.52 and 0.32±0.08%. Results from this research demonstrate that feeding NSP to lactating cows is an effective method to reduce the transfer and excretion of AFM1 in milk with no negative effects on dry matter intake, milk production, and composition.

show abstract

Section: Sampling and Data Collectionmentioning

confidence: 99%

Effects of calcium montmorillonite clay and aflatoxin exposure on dry matter intake, milk production, and milk composition

Maki

Thomas

Elmore

et al. 2016

Journal of Dairy Science

Self Cite

View full text Add to dashboard Cite

show abstract

“…Specifically, the addition of 2% AB20A reduce protein content in water soluble fraction by 32% in the pH 2.0 and 44% in the pH 8.0 water-soluble fractions. The layered crystalline microstructure of clays with exchangeable cations has been demonstrated to adsorb aflatoxin [61,62]. It has been hypothesized that organic substances adsorb to external or interlayer surfaces of negatively charged bentonite clays due to interactions between aflatoxin carbonyl groups and clay exchangeable cations [63].…”

Section: Aflatoxin Decontaminationmentioning

confidence: 99%

Peanut proteins: Applications, ailments and possible remediation

Ghatak

Sen

2013

Journal of Industrial and Engineering Chemistry

View full text Add to dashboard Cite

“…36,[46][47][48] Results of NS clay phase I and II clinical trials suggest that ingestion of up to 3 g/ day in adults is safe for a 3-month period. [49][50][51] Based on detailed studies conducted in animals and humans, it was determined that ingestion of UPSN at levels efficacious for reducing AFB 1 biomarkers would be reasonably safe in children.…”

Section: Introductionmentioning

confidence: 99%

Short-Term Safety and Efficacy of Calcium Montmorillonite Clay (UPSN) in Children

Mitchell¹,

Kumi²,

Aleser³

et al. 2014

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. Recently, an association between childhood growth stunting and aflatoxin (AF) exposure has been identified. In Ghana, homemade nutritional supplements often consist of AF-prone commodities. In this study, children were enrolled in a clinical intervention trial to determine the safety and efficacy of Uniform Particle Size NovaSil (UPSN), a refined calcium montmorillonite known to be safe in adults. Participants ingested 0.75 or 1.5 g UPSN or 1.5 g calcium carbonate placebo per day for 14 days. Hematological and serum biochemistry parameters in the UPSN groups were not significantly different from the placebo-controlled group. Importantly, there were no adverse events attributable to UPSN treatment. A significant reduction in urinary metabolite (AFM 1 ) was observed in the high-dose group compared with placebo. Results indicate that UPSN is safe for children at doses up to 1.5 g/day for a period of 2 weeks and can reduce exposure to AFs, resulting in increased quality and efficacy of contaminated foods.

show abstract

NovaSil clay does not affect the concentrations of vitamins A and E and nutrient minerals in serum samples from Ghanaians at high risk for aflatoxicosis

Cited by 39 publications

References 44 publications

Effects of calcium montmorillonite clay and aflatoxin exposure on dry matter intake, milk production, and milk composition

Effects of calcium montmorillonite clay and aflatoxin exposure on dry matter intake, milk production, and milk composition

Peanut proteins: Applications, ailments and possible remediation

Short-Term Safety and Efficacy of Calcium Montmorillonite Clay (UPSN) in Children

Contact Info

Product

Resources

About