2021
DOI: 10.2147/jir.s330614
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Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]Pyridazinone Exert Anti-Inflammatory Activity without Acute Gastrotoxicity in the Carrageenan-Induced Rat Paw Edema Test

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Cited by 16 publications
(17 citation statements)
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“…One hour after administration of the appropriate experimental substance, a single injection under the plantar aponeurosis of the right hint footpad was performed. Animals received either 100 μ L of 0.9% saline solution (CON group) or 100 μ L of 1% carrageenan solution (all other groups) as described by other authors [ 29 , 30 ] [ 29 , 30 ]. The paw volume was measured with a plethysmometer (Plethysmometer 37140 Ugo Basile, Gemonio, Italy) five times in each animal: before the injection of carrageenan/saline solution and 1, 2, 3, and 6 hours after the injection.…”
Section: Methodsmentioning
confidence: 99%
“…One hour after administration of the appropriate experimental substance, a single injection under the plantar aponeurosis of the right hint footpad was performed. Animals received either 100 μ L of 0.9% saline solution (CON group) or 100 μ L of 1% carrageenan solution (all other groups) as described by other authors [ 29 , 30 ] [ 29 , 30 ]. The paw volume was measured with a plethysmometer (Plethysmometer 37140 Ugo Basile, Gemonio, Italy) five times in each animal: before the injection of carrageenan/saline solution and 1, 2, 3, and 6 hours after the injection.…”
Section: Methodsmentioning
confidence: 99%
“…The cytokine levels of TNF-α, IL-10, IL-6 and IL-1B in T. gondii -infected mouse sera were examined by enzyme-linked immunosorbent assay (ELISA) kits (R&D Systems, Minneapolis, USA) according to the manufacturer’s protocols. The reaction was measured by a microplate reader (Absorbance 96, Byonoy, Germany) at 450 nm [ 7 , 34 ].…”
Section: Methodsmentioning
confidence: 99%
“…These compounds in all studied doses (10 and 20 mg/kg) caused negligible mucosal lesions compared to indomethacin at a dose of 10 mg/kg which showed significant mucosal injuries ranging from hyperemia to hemorrhagic lesions. [73] 1,3,4-Oxadiazole derivatives of pyrrolo [3,4-d] (catalog no. 701050).…”
Section: Anti-inflammatory Activity Of Isoxazolo[45-d] Pyridazinonesmentioning
confidence: 99%