Novel 1‐Aminomethylisatins: Peculiarities of the Synthesis and the Reaction with Tris(diethylamino)phosphine

Abstract

in Wiley Online Library (wileyonlinelibrary.com).The Mannich reaction of isatin with different primary and secondary amines and effect of the substituent in aromatic amines on the reaction pathway is studied. The efficient high-yield synthesis of novel isoindigo derivatives by the mild deoxygenation reaction of the corresponding isatins with tris (diethylamino)phosphine is described.

Advances in the synthesis and application of isoindigo derivatives

“…[41][42][43][44][45][46][47][48][49][50][51][52] In this type of 3,3′-bis-indole fragment formation a wide range of isatin derivatives including benzothiphene-or benzofuran-fused ones 53 can be used. Using this procedure the target compounds were obtained in high yields under mild reaction conditions (Scheme 11).…”