Novel 11,12H-dihydronaphthalene[1,2-b]quinoline as Atypical Antipsychotic

Moran, Maria; Guio, Jorge E. Angel; Cano, Natividad Herrera; Migliore, Biagina del Carmen; Izquierdo, Rodolfo; Charris, Jaime; López, Simón E.; Israel, A; Santiago, Ana N.; Rossi, Roberto A.; Perdomo, Luis; Dabian, Akram; Sosa, Mariagracia Vera; Villalba, Alejandra del Valle; Migliore, Ligia Biagina Angel

doi:10.2174/1570180814666170704144246

Cited by 4 publications

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“…Quinoline (benzo[b]pyridine or 1‐azanaphthalene) is an applicant of N ‐containing heterocyclic motif in chemistry, medicine, and biology. Various kinds of compounds bearing quinolone building‐blocks demonstrated numerous properties such as antitumor, [ 1 ] anti‐inflammatory, [ 2 ] antiviral, [ 3 ] antimalarial, [ 4 ] antifungal, [ 5 ] antibacterial, [ 6 ] anticancer, [ 7 ] antipsychotic, [ 8 ] anti‐HIV, [ 9 ] antituberculosis, [ 10 ] and antioxidant [ 11 ] activities. In addition, various quinolone‐containing compounds, applied in several branches of science and technology, exhibited interesting properties like electrochemical and antiplasmodium properties, [ 12 ] fluorescence and cell imaging, [ 13 ] optoelectronic, [ 14 ] and rubber chemicals.…”

Section: Introductionmentioning

confidence: 99%

Cascade embedding triethyltryptophanium iodide ionic liquid (TrpEt₃⁺I⁻) on silicated titanomagnetite core (Fe_3‐xTi_xO₄‐SiO₂@TrpEt₃⁺I⁻): A novel nano organic–inorganic hybrid to prepare a library of 4‐substituted quinoline‐2‐carboxylates and 4,6‐disubstituted quinoline‐2‐carboxylates

Nikoofar

Yielzoleh

2021

J Chinese Chemical Soc

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A library of substituted quinolone‐2‐carboxylates (4,6‐disubstituted quinolone‐2‐carboxylates, 6‐substituted quinoline dialkyl‐2,4‐dicarboxylates, and 6‐substituted 4‐[2‐methoxy‐2‐oxoethyl]quinoline‐2‐methylcarboxylates) was obtained through different scopes of one‐pot and one‐step MCRs such as (a) three‐component reaction of aromatic amines, dialkyl acetylenedicarboxylates, and terminal alkenes/ketones; (b) pseudo three‐component reaction of anilines and dialkyl acetylenedicarboxylates; and (c) pseudo three‐component reaction of anilines and methyl propiolate under solvent‐free conditions at 100°C. The promoter of these annulation processes is a novel inorganic–organic core–shell that was obtained from silicated titanomagnetite, tryptophan amino acid, and ethyl iodide. The tryptophan embedded on the silicated titanomagnetite core (Fe3‐xTixO4‐SiO2) followed by alkylation with ethyl iodide subsequently result in in situ preparation of triethyltryptophanium iodide ionic liquid (TrpEt3+I−). The final nanohybrid (Fe3‐xTixO4‐SiO2@TrpEt3+I−) was characterized by field‐emission scanning electron microscope, EDAX, FT‐IR, TGA/DTG, vibrating sample magnetometer, and X‐ray fluorescence techniques. The highlighted features of the protocol are as follows: (a) synthesis of a vast range of substituted quinolines through a straightforward method from simple substrates under solvent‐free conditions, (b) utilizing various scopes of functionalities as substrates, (c) simple separation of the nano promoter via an external magnet, (d) regioselectivity in the cascade annulation procedure, and (e) recovery and reusability of the nanocomposite within three runs without significant activity loss.

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Section: Introductionmentioning

confidence: 99%

Cascade embedding triethyltryptophanium iodide ionic liquid (TrpEt₃⁺I⁻) on silicated titanomagnetite core (Fe_3‐xTi_xO₄‐SiO₂@TrpEt₃⁺I⁻): A novel nano organic–inorganic hybrid to prepare a library of 4‐substituted quinoline‐2‐carboxylates and 4,6‐disubstituted quinoline‐2‐carboxylates

Nikoofar

Yielzoleh

2021

J Chinese Chemical Soc

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“…Among them, quinoline is one of the most privileged heteroaromatics, in view of its excellent biological and pharmacological activities. For instance, it possesses antibacterial, 1 antifungal, 2,3 antimalarial, 4 antipsychotic, 5 anticancer, 6,7 anthelmintic, 8 antiglaucoma, 9 and cardiotonic 9 activities. Besides, quinoline skeletons are utilized in ligands, [10][11][12][13] agrochemicals, 14 functional materials, [15][16][17] and so on.…”

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confidence: 99%

One-Pot Synthesis of 2-Arylquinolines via in situ Acid Catalysis

Qiang

Cai

et al. 2022

Synthesis

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A simple, efficient, and practical protocol has been reported, allowing quick access to diverse 2-arylquinolines from 2-vinylanilines and benzyl halides. This reaction is additive and metal catalyst-free with only solvent needed. A preliminary mechanistic investigation discloses the driving force come from the in situ released HBr, which catalyzes the subsequent cyclization. The present synthetic route featured high functional group tolerance and simple post-processing. A variety of 2-arylquinolines were obtained up to 96% yield.

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Efficient synthesis of perfluoroalkylated quinolines via a metal-free cascade Michael addition/intramolecular rearrangement cyclization process

Zhang

Ding

et al. 2020

Tetrahedron

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Novel 11,12H-dihydronaphthalene[1,2-b]quinoline as Atypical Antipsychotic

Cited by 4 publications

References 0 publications

One-Pot Synthesis of 2-Arylquinolines via in situ Acid Catalysis

Efficient synthesis of perfluoroalkylated quinolines via a metal-free cascade Michael addition/intramolecular rearrangement cyclization process

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