Novel 2-(1-(substitutedbenzyl)-1H-tetrazol-5-yl)-3-phenylacrylonitrile derivatives: synthesis, in vitro antitumor activity and computational studies

Maddila, Suresh; Naicker, Kovashnee; Momin, Mehbub I. K.; Rana, Surjyakanta; Gorle, Sridevi; Maddila, Suryanarayana; Yalagala, Kotaiah; Singh, Moganavelli; Koorbanally, Neil A.; Jonnalagadda, Sreekantha B.

doi:10.1007/s00044-015-1482-x

Cited by 29 publications

(8 citation statements)

References 40 publications

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“…In continuation of our research efforts in the direction of synthesis of various heterocyclic molecules via MCRs under green conditions, recently we have reported the preparation of several novel heterocyclic protocols via multicomponent reaction in the presence of different heterogeneous catalysts . Further, we have also reported biological active heterocyclic molecules . In this study we have reported a facile and green approach for the synthesis of poly‐functionalized 1,4‐dihydropyridine derivatives under catalyst‐free conditions in EtOH via MWI for the first time.…”

Section: Introductionmentioning

confidence: 87%

Microwave‐Assisted Multicomponent Reaction: A Green and Catalyst‐Free Method for the Synthesis of Poly‐Functionalized 1,4‐Dihydropyridines

Maddila

Kerru

Chinnam³

et al. 2019

ChemistrySelect

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A facile and an efficient procedure for the synthesis of poly‐substituted 1,4‐dihydropyridine derivatives under catalyst‐free conditions has been established by a one‐pot multi‐component reaction in EtOH solvent under microwave irradiation (150 W). The remarkable benefits of this approach are: simple operation, non‐toxic, short reaction time (< 5 min), excellent yields (93‐98%), no column chromatography, clean reaction profile and environmentally friendly reaction.

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Section: Introductionmentioning

confidence: 87%

Microwave‐Assisted Multicomponent Reaction: A Green and Catalyst‐Free Method for the Synthesis of Poly‐Functionalized 1,4‐Dihydropyridines

Maddila

Kerru

Chinnam³

et al. 2019

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“…In our continuous efforts to develop swift and green methodologies for the generation of novel heterocyclic molecules, earlier we have reported various highly efficient methods for synthesis of different condensed heterocyclic frameworks . We have also evaluated the biological activity of few series . The present protocol emphasizes the synthesis of new RuO 2 /FAp materials of different compositions and their scope as catalysts for preparation of novel arylsulfonyl‐4H‐pyrans in excellent yields, by the reaction of certain aromatic aldehydes, phenylsulphonyl acetonitrile and dimedone at room temperature with EtOH as green solvent.…”

Section: Introductionmentioning

confidence: 99%

Facile One‐pot Synthesis of Arylsulfonyl‐4H‐pyrans Catalyzed by Ru Loaded Fluorapatite

Maddila

Kerru

et al. 2020

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We report a novel ecofriendly cascade reaction for the synthesis of arylsulfonyl-4H-pyran derivatives by a three component fusion reaction of chosen aldehyde, dimedone and phenylsulphonyl acetonitrile at room temperature using ruthenia doped fluorapatite (RuO 2 /FAp) as recyclable catalyst. Different percentages of RuO 2 /FAp materials were prepared and characterized by FT-IR, P-XRD, BET, SEM-EDX and TEM analysis. Attractive features of the synthetic approach are operational simplicity, cost-effectiveness, short reaction time and excellent yields. Easily recoverable and reusable catalyst material without any deceptive loss of catalytic activity up to seven cycles is additional benefit.

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“…In our continuous quest for evolving facile and efficient approaches for the synthesis of diverse heterocycles via MCR methodologies [38–40], we have earlier reported the protocols for the synthesis of several heterocyclic biological active molecules [41–44]. The current work focus on the microwave irradiation approach for the first time, for the synthesis of a new series of benzopyran derivatives, through one-pot reaction of aromatic aldehyde, methyl cyanoacetate and 1,3-cyclohexadione using water as solvent.…”

Section: Introductionmentioning

confidence: 99%

A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation

Khumalo¹,

Maddila²,

Jonnalagadda³

2019

BMC Chemistry

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Eleven new tetrahydrobenzo[b]pyran derivatives were synthesized via a three component reaction of different aromatic aldehydes, methyl cyanoacetate and 1,3-cyclohexadione, with water as solvent under catalyst-free microwave irradiation. The structures of all the new molecules were well analysed and their structures established by using various spectral techniques (1H NMR, 13C NMR, 15N NMR and HRMS). Various advantages of reported protocol are the ease of preparation, short reaction times (10 min), aqueous solvent and excellent yields (89–98%). Additionally, this method provides a clean access to the desired products by simple workup.

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Novel 2-(1-(substitutedbenzyl)-1H-tetrazol-5-yl)-3-phenylacrylonitrile derivatives: synthesis, in vitro antitumor activity and computational studies

Cited by 29 publications

References 40 publications

Microwave‐Assisted Multicomponent Reaction: A Green and Catalyst‐Free Method for the Synthesis of Poly‐Functionalized 1,4‐Dihydropyridines

Microwave‐Assisted Multicomponent Reaction: A Green and Catalyst‐Free Method for the Synthesis of Poly‐Functionalized 1,4‐Dihydropyridines

Facile One‐pot Synthesis of Arylsulfonyl‐4H‐pyrans Catalyzed by Ru Loaded Fluorapatite

A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation

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