Novel 2-substituted-quinoxaline analogs with potential antiproliferative activity against breast cancer: insights into cell cycle arrest, topoisomerase II, and EGFR activity

Salem, Manar G.; Abu El-ata, Sara A.; Elsayed, Elsherbiny H.; Mali, Suraj N.; Alshwyeh, Hussah Abdullah; Almaimani, Ghassan; Almaimani, Riyad A.; Almasmoum, Hussain A.; Altwaijry, Najla; Al-Olayan, Ebtesam; Saied, Essa M.; Youssef, Mohamed F.

doi:10.1039/d3ra06189b

Cited by 6 publications

(1 citation statement)

References 105 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cell cycle analysis was performed using the propidium iodide (PI) flow cytometry kit (ab139418, Abcam, USA) by measuring the DNA content using a flow cytometer following the manufacturer's instructions. 43,53,54 Briefly, the CIR was dispersed in the cells, centrifugated at 500 g for 5 minutes, washed with 1× PBS, fixed with 66% ethanol on ice and resuspension of the cell pellet in 1× PBS followed by 100% ethanol. The subsequent PI staining procedure involved equilibrating the cells at room temperature, washing with 1× PBS and resuspending the cells in 1× PI + RNase staining solution.…”

Section: Methodsmentioning

confidence: 99%

Unveiling the multifaceted antiproliferative efficacy of Cichorium endivia root extract by dual modulation of apoptotic and inflammatory genes, inducing cell cycle arrest, and targeting COX-2

Alzahrani,

Hosny,

Mohamed

et al. 2024

RSC Adv.

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Unveiling the multifaceted antiproliferative efficacy of Cichorium endivia root extract by dual modulation of apoptotic and inflammatory genes, inducing cell cycle arrest, and targeting COX-2

Alzahrani,

Hosny,

Mohamed

et al. 2024

RSC Adv.

Self Cite

View full text Add to dashboard Cite

show abstract

The current landscape of coumarin hybrids with antibreast cancer therapeutic applications: An updated review

Wang,

Chen,

Huang

et al. 2024

Archiv der Pharmazie

View full text Add to dashboard Cite

Globally, breast cancer (BC) has the highest prevalence among malignant diseases. BC is also the primary cause of death among women. Notably, BC morbidity has been increasing continuously at an approximate growth rate of 2.2% per year. Persistent BC is a major public health issue worldwide. Consequently, novel chemotherapeutic agents to combat this lethal disease should be developed urgently. Coumarins with interesting structural and mechanistic variations exhibit promising activity in several forms of BC, including BCs with multidrug resistance. In particular, coumarin hybrids composed of coumarin and one or more anti‐BC pharmacophores can target different biological components in BC cells simultaneously. Thus, coumarin hybrids are useful scaffolds that can help improve the anti‐BC efficacy of coumarins, reduce side effects, improve pharmacokinetics, minimize drug–drug interactions, and circumvent drug resistance. This review, in which articles published from 2020 to the present day have been evaluated, highlights the landscape of coumarin hybrids that exhibit therapeutic effects against breast cancer. These findings can aid further investigations on novel antibreast‐cancer therapeutics.

show abstract

Emerging Trends in Quinoxaline‐Based Analogs as Protein Kinase Inhibitors: Structural Developments and SAR Insights

Shivani,

Mahajan,

Chaudhary

2024

ChemMedChem

View full text Add to dashboard Cite

Cancer remains a leading cause of mortality and has been recognized as a significant global health concern. Although numerous effective anticancer agents are available; most of the current drugs lack specificity, leading to common side‐effects associated with chemotherapy. Recent research, however, offers promise for developing more targeted and safer anticancer therapies through protein kinase inhibition. Quinoxaline derivatives represent a notable class of heterocyclic compounds. The extensive spectrum of biological activities demonstrated by quinoxalines has garnered substantial research interest. Quinoxaline and its derivatives have emerged as a novel class of chemotherapeutic agents with significant activity against various tumors through protein kinase inhibition. This review aims to elucidate recent advancements in the quinoxaline derivatives targeting protein kinase along with structural developments and structure‐activity relationships associated with these compounds.

show abstract

Novel 2-substituted-quinoxaline analogs with potential antiproliferative activity against breast cancer: insights into cell cycle arrest, topoisomerase II, and EGFR activity

Abstract: We reported a novel 2-coumarin-substituted-quinoxaline analogue (3b) with potential antiproliferative activity against MCF-7 breast cancer cells by inducing cell cycle arrest and targeting topoisomerase II, and EGFR activity.

Cited by 6 publications

References 105 publications

Unveiling the multifaceted antiproliferative efficacy of Cichorium endivia root extract by dual modulation of apoptotic and inflammatory genes, inducing cell cycle arrest, and targeting COX-2

Unveiling the multifaceted antiproliferative efficacy of Cichorium endivia root extract by dual modulation of apoptotic and inflammatory genes, inducing cell cycle arrest, and targeting COX-2

The current landscape of coumarin hybrids with antibreast cancer therapeutic applications: An updated review

Emerging Trends in Quinoxaline‐Based Analogs as Protein Kinase Inhibitors: Structural Developments and SAR Insights

Contact Info

Product

Resources

About