Novel [3+2] and [3+3] 4-quinolone annulations by tandem Claisen-Cope amidoalkylation reaction

Single‐Step Synthesis of 3‐Iodoquinolines from 2‐Aminophenyl Ketones through a Regioselective (6‐endo‐dig) Electrophilic Cyclization

“…Because of their diverse applications, the synthesis of quinoline and its derivatives has become an active area of research that ranges from well‐known classic reactions such as the Combes synthesis, the Conrad–Limpach–Knorr synthesis, the Friedländer reaction, and the Skraup–Doebner–von Miller reaction to metal‐catalyzed approaches . Among quinoline derivatives, halogenated quinolones are particularly of special interest as they provide a viable platform for further functionalization …”

A convenient and efficient C–OH bond activation, PdCl2(PPh3)2catalyzed, C–C bond formation of tautomerizable quinolinones with the aid of BOP reagent and boronic acids

“…[35][36][37] Halogen-containing quinolines demonstrates potential bioactivity and the chloro functionality plays a great role in further structural modications. [38][39][40][41][42][43][44] In spite of a wide range of pharmacological activities and numerous reports on their synthetic methods, [45][46][47][48][49][50][51][52][53][54] there is a need for the development of a new, simple, convenient, and environmentally benign synthetic approach for the 2-substituted quinolines using mild conditions and it remains an active research area.…”

Green chemical approach: microwave assisted, titanium dioxide nanoparticles catalyzed, convenient and efficient C–C bond formation in the synthesis of highly functionalized quinolines and quinolinones

“…[25][26][27] The halogen containing quinolines are a great source for further structural modications. [28][29][30][31][32][33][34] Similarly the 2,3-position substituted quinolines have shown in vivo activities against Leishmania donovani [35][36][37] and are in preclinical development. [38][39][40][41] They display substantial antiviral activity in HIV-infected cells, [42][43][44][45][46][47] anticancer, [48][49][50][51][52] antimalarial activities.…”