Novel 3,4-seco-3,19-dinorspongian and 5,17-epoxy-19-norspongian diterpenes from the marine spongeSpongiasp.

Abstract

Twelve new norspongian diterpenes, dinorspongians A-F (1–6) and epoxynorspongians A–F (7–12), were isolated from the marine sponge Spongia sp.

Marine natural products

“…466 Spongian diterpenoids are commonly reported from Dictyoceratid and Dendroceratid sponges. Twelve new nor-spongians 1085–1096 came from a Spongia sp., 467 while 1097 and 1098 are “classic” spongian diterpenoids from Acanthodendrilla sp. 468 Collections of Dendrilla antarctica from Antarctica over several years resulted in two reports of rearranged spongian diterpenoids, new dendrillins 1099–1101 from one, 469 and several new membranoids 1102–1108 from the other.…”

New 3,4-seco-3,19-Dinor- and Spongian-Based Diterpenoid Lactones from the Marine Sponge Spongia sp.

“…Spongian diterpenoids and structurally related metabolites are a series of natural products with unique structures distributed in sponges of the genus Spongia , and the structural diversity and potential biological significance of these compounds are well known [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. Recently, we have reported the discovery of new spongian diterpenes, including four rare 5,5,6,6,5-pentacyclic diterpenoids, from a Red Sea sponge, Spongia sp.…”

Spongenolactones A–C, Bioactive 5,5,6,6,5-Pentacyclic Spongian Diterpenes from the Red Sea Sponge Spongia sp.

“…Sponges of the genus Spongia have been proven to be rich sources of structurally diversified secondary metabolites [ 1 , 2 ]. A series of previous studies for the discovery of versatile molecular structures and bioactivities of compounds from sponges of the genus Spongia have been reported [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. Our recent investigation on the secondary metabolites of a Red Sea sponge Spongia sp.…”