4‐Benzothiazolylamino‐6‐methyl‐2H[1]‐pyran‐2‐one 6a , 4‐(4‐Methylbenzothiazolylamino)‐6‐methyl‐2H[1]‐pyran‐2‐one 6b , 4‐(5,6‐dimethylbenzothiazolylamino)‐6‐methyl‐2H[1]‐pyran‐2‐one 6c and substituted 4‐(Benzothiazolylamino)‐6‐methyl‐3‐nitro‐2H[1]‐pyran‐2‐ones 6(d, e) are synthesized by condensation of 4‐Chlor‐6 methylpyran‐2‐ones (2, 4) and corresponding benzithiazolylamines 5(a‐e) under reflux reaction conditions. The antibacterial activity of products 4(a‐d) against Staphylococcus aureus, Clebsiella and Escherichia coli were investigated. Compounds 6(a‐e) showed light bactericide activity against Staphylococcus aureus, Escherichia coli and Clebsiella. Compounds 6e and 6c were more active against Staphylococcus aureus. Compounds 6d and 6b exhibited the strongest activity against Clebsiella, whereas 6e was more active against Escherichia coli. In general there was a driect positive correlation between increasing concentration of the compound and anitbacterial activity.