Novel 3D integrated microfluidic device: Design, construction, and application to the preparation of liposomes for vaccine delivery

Xiu, Xueliang; Ma, Shichao; Li, Zhiyong; Li, Zhipeng; Li, Xuemei; Ruan, Yangtao; Li, Dezhao; Wang, Jianwei; Ma, Fengsen

doi:10.1016/j.jddst.2023.105191

Journal of Drug Delivery Science and Technology

2024

DOI: 10.1016/j.jddst.2023.105191

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Novel 3D integrated microfluidic device: Design, construction, and application to the preparation of liposomes for vaccine delivery

Xueliang Xiu,

Shichao Ma,

Zhiyong Li

et al.

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Cited by 2 publications

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Liposomes, transfersomes and niosomes: production methods and their applications in the vaccinal field

Riccardi,

Baldino,

Reverchon

2024

J Transl Med

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One of the most effective strategies to fight viruses and handle health diseases is vaccination. Recent studies and current applications are moving on antigen, DNA and RNA-based vaccines to overcome the limitations related to the conventional vaccination strategies, such as low safety, necessity of multiple injection, and side effects. However, due to the instability of pristine antigen, RNA and DNA molecules, the use of nanocarriers is required. Among the different nanocarriers proposed for vaccinal applications, three types of nanovesicles were selected and analysed in this review: liposomes, transfersomes and niosomes. PubMed, Scopus and Google Scholar databases were used for searching recent papers on the most frequently used conventional and innovative methods of production of these nanovesicles. Weaknesses and limitations of conventional methods (i.e., multiple post-processing, solvent residue, batch-mode processes) can be overcome using innovative methods, in particular, the ones assisted by supercritical carbon dioxide. SuperSomes process emerged as a promising production technique of solvent-free nanovesicles, since it can be easily scaled-up, works in continuous-mode, and does not require further post-processing steps to obtain the desired products. As a result of the literature analysis, supercritical carbon dioxide assisted methods attracted a lot of interest for nanovesicles production in the vaccinal field. However, despite their numerous advantages, supercritical processes require further studies for the production of liposomes, transfersomes and niosomes with the aim of reaching well-defined technologies suitable for industrial applications and mass production of vaccines.

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Liposomes, transfersomes and niosomes: production methods and their applications in the vaccinal field

Riccardi,

Baldino,

Reverchon

2024

J Transl Med

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3D Printing of High-Porosity Membranes with Submicron Pores for Microfluidics

Hoskins,

Zou

2024

Nanomanufacturing

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In this study, we investigate the potential of two-photon lithography (2PL) as a solution to the challenges encountered in conventional membrane fabrication techniques, aiming to fabricate tailor-made membranes with high-resolution submicron pore structures suitable for advanced applications. This approach led to the development of fabrication techniques and printed membranes that can be adapted to various lab-on-a-chip (LOC) devices. Membranes were fabricated with pore diameters as small as 0.57 µm and porosities of 4.5%, as well as with larger pores of approximately 3.73 µm in diameter and very high porosities that reached up to 60%. Direct 3D printing of membranes offers a pathway for fabricating structures tailored to specific applications in microfluidics, enabling more efficient separation processes at miniature scales. This research represents a significant step towards bridging the gap between membrane technology and microfluidics, promising enhanced capabilities for a wide array of applications in biotechnology, chemical analysis, and beyond.

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Novel 3D integrated microfluidic device: Design, construction, and application to the preparation of liposomes for vaccine delivery

Cited by 2 publications

References 47 publications

Liposomes, transfersomes and niosomes: production methods and their applications in the vaccinal field

Liposomes, transfersomes and niosomes: production methods and their applications in the vaccinal field

3D Printing of High-Porosity Membranes with Submicron Pores for Microfluidics

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