Novel 4-in-1 strategy to combat colon cancer, drug resistance and cancer relapse utilizing functionalized bioinspiring lignin nanoparticle

Siddiqui, Lubna; Mishra, Harshita; Mishra, Pawan Kumar; Iqbal, Zeenat; Talegaonkar, Sushama

doi:10.1016/j.mehy.2018.09.003

Cited by 44 publications

(20 citation statements)

References 38 publications

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“…As shown, our data revealed that P-gp downregulation was consistent with inhibition of SMYD2-OE expression in SW620 cells, and accordingly, the P-gp upregulation with the increased SMYD2-OE in SW480 cells (Figure 3A–C). Previous study has indicated that P-gp expression was upregulated26 in COAD and overexpression of P-gp promoted L-OHP resistance in colon cancer cells. These data indicated that P-gp was very important for SMYD2-OE-mediated L-OHP resistance in COAD.…”

Section: Resultsmentioning

confidence: 94%

<p>SMYD2-OE promotes oxaliplatin resistance in colon cancer through MDR1/P-glycoprotein via MEK/ERK/AP1 pathway</p>

Ren

Wang²,

Chen

et al. 2019

OTT

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Background: SET and MYND domain-containing protein 2 (SMYD2-OE) plays an important role in cancer development through methylating histone and non-histone proteins. However, little is known about the relevance of SMYD2-OE in colon cancer. Moreover, oxaliplatin (L-OHP) is applied as first line for colon cancer chemotherapy, but drug resistance restricts its efficacy. Unexpectedly, the mechanism of L-OHP resistance in colon cancer remains unclear. In this study, we investigated the relationship of SMYD2-OE expression and L-OHP resistance in colon cancer and further explored the underlying mechanism linking SMYD2-OE, L-OHP resistance, and colon cancer. Materials and methods: Expression levels of SMYD2-OE in colon cancer tissues of patients were tested. In vitro and in vivo assays were conducted to explore the function and mechanism of SMYD2-OE in colon cancer sensitivity to L-OHP. Results: SMYD2-OE was overexpressed in colon cancer tissues compared with non-neoplastic tissues and associated with poor prognosis of patients with colon cancer after L-OHP-based chemotherapy. Knockdown of SMYD2-OE increased colon cancer sensitivity to L-OHP in vitro and in vivo. However, SMYD2-OE overexpression promoted L-OHP resistance in colon cancer cell in vitro. In addition, SMYD2-OE could upregulate MDR1/P-glycoprotein expression depending on MEK/ERK/AP-1 signaling pathway activity. Conclusion: These results imply that SMYD2-OE promotes L-OHP resistance in colon cancer by regulating MDR1/P-glycoprotein through MEK/ERK/AP-1 signaling pathway, providing a potential strategy to sensitize che-motherapy by SMYD2-OE knockdown in colon cancer treatment.

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Section: Resultsmentioning

confidence: 94%

<p>SMYD2-OE promotes oxaliplatin resistance in colon cancer through MDR1/P-glycoprotein via MEK/ERK/AP1 pathway</p>

Ren

Wang²,

Chen

et al. 2019

OTT

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“…The recent rise in reports of self-assembled lignin nanostructures with size tunability and morphology control adds a new dimension to the high-value applications of lignin [4,5,6,7]. The lignin nanostructure utilization in surfactants [8,9], UV protection [10,11], composites [12,13,14,15], and drug delivery [16,17,18,19] are among some of the latest reported studies (Figure 2). In this paper, we attempt to elucidate the progress in understanding 1) the process of lignin self-assembly in xylogenesis and in plant cell wall formation, 2) aggregation propensity and the effect of reaction conditions, 3) noncovalent interactions in molecular and supramolecular self-assembly, and 4) nanostructure formation.…”

Section: Introductionmentioning

confidence: 99%

The Self-Assembly of Lignin and Its Application in Nanoparticle Synthesis: A Short Review

2019

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Lignin serves as a significant contributor to the natural stock of non-fossilized carbon, second only to cellulose in the biosphere. In this review article, we focus on the self-assembly properties of lignin and their contribution to its effective utilization and valorization. Traditionally, investigations on self-assembly properties of lignin have aimed at understanding the lignification process of the cell wall and using it for efficient delignification for commercial purposes. In recent years (mainly the last three years), an increased number of attempts and reports of technical-lignin nanostructure synthesis with controlled particle size and morphology have been published. This has renewed the interests in the self-assembly properties of technical lignins and their possible applications. Based on the sources and processing methods of lignin, there are significant differences between its structure and properties, which is the primary obstacle in the generalized understanding of the lignin structure and the lignification process occurring within cell walls. The reported studies are also specific to source and processing methods. This work has been divided into two parts. In the first part, the aggregation propensity of lignin based on type, source and extraction method, temperature, and pH of solution is discussed. This is followed by a critical overview of non-covalent interactions and their contribution to the self-associative properties of lignin. The role of self-assembly towards the understanding of xylogenesis and nanoparticle synthesis is also discussed. A particular emphasis is placed on the interaction and forces involved that are used to explain the self-association of lignin.

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“…It has also provided an impetus to the search for structurally homogeneous lignin that can be easily applied in efficient and scalable technology for lignin-based reagents production [8]. The relatively new addition in lignin-based clean (biocompatible and non-toxic) products include nanomaterials and those used in biomedical applications [9][10][11]. As presented in Figure 1, a multi-fold rise in the number of patents registered in the Scopus database in the period of the last 20 years (2000-2019) can be seen.…”

Section: Introductionmentioning

confidence: 99%

“…As presented in Figure 1, a multi-fold rise in the number of patents registered in the Scopus database in the period of the last 20 years (2000-2019) can be seen. The maximum number of patents were registered in the United States Patent and Trademark Office (45,268), followed by the Japan Patent Office (16,547), the World Intellectual property organization (10,657), the European Patent office (8180) and the United Kingdom Intellectual Property office (332). These results were obtained from the Scopus database Technical lignin is derived mainly from lignocellulosic biomass, and therefore its structure directly depends on the source and method of extraction.…”

Section: Introductionmentioning

confidence: 99%

Lignin for Bioeconomy: The Present and Future Role of Technical Lignin

Ekielski

Mishra

2020

IJMS

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Lignin, the term commonly used in literature, represents a group of heterogeneous aromatic compounds of plant origin. Protolignin or lignin in the cell wall is entirely different from the commercially available technical lignin due to changes during the delignification process. In this paper, we assess the status of lignin valorization in terms of commercial products. We start with existing knowledge of the lignin/protolignin structure in its native form and move to the technical lignin from various sources. Special attention is given to the patents and lignin-based commercial products. We observed that the technical lignin-based commercial products utilize coarse properties of the technical lignin in marketed formulations. Additionally, the general principles of polymers chemistry and self-assembly are difficult to apply in lignin-based nanotechnology, and lignin-centric investigations must be carried out. The alternate upcoming approach is to develop lignin-centric or lignin first bio-refineries for high-value applications; however, that brings its own technological challenges. The assessment of the gap between lab-scale applications and lignin-based commercial products delineates the challenges lignin nanoparticles-based technologies must meet to be a commercially viable alternative.

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Novel 4-in-1 strategy to combat colon cancer, drug resistance and cancer relapse utilizing functionalized bioinspiring lignin nanoparticle

Cited by 44 publications

References 38 publications

<p>SMYD2-OE promotes oxaliplatin resistance in colon cancer through MDR1/P-glycoprotein via MEK/ERK/AP1 pathway</p>

<p>SMYD2-OE promotes oxaliplatin resistance in colon cancer through MDR1/P-glycoprotein via MEK/ERK/AP1 pathway</p>

The Self-Assembly of Lignin and Its Application in Nanoparticle Synthesis: A Short Review

Lignin for Bioeconomy: The Present and Future Role of Technical Lignin

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