Novel 5‐Hydroxy, 5‐Substituted Benzenesulfonamide Pyrimidine‐2,4,6‐Triones Attenuate Lipopolysaccharide‐Induced Acute Lung Injury via Inhibition of the Gelatinases, MMP‐2 and MMP‐9

Abstract

Preclinical Research A novel series of ten 5-hydroxy, 5-substituted benzene sulfonamide pyrimidine-2,4,6-triones were synthesized and their structures ascertained using (1) H-NMR, (13) C-NMR, mass and elemental analysis. These compounds were subsequently tested for inhibition of MMP-2 and MMP-9 where most exhibited activity with compound 5i being the most potent against MMP-2 and MMP-9 with IC50 values of 2.35 nM and 8.24 nM, respectively. Compound 5i was further analyzed in a mouse LPS-induced acute lung injury model where it had protective activity. Histochemical studies indicated that 5i improved the vascular integrity of the lung. Drug Dev Res 77 : 251-257, 2016. © 2016 Wiley Periodicals, Inc.

Protective effect of baicalin against severe burn‑induced remote acute lung injury in rats

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