Novel 8-(furan-2-yl)-3-benzyl thiazolo [5,4-e][1,2,4] triazolo [1,5-c] pyrimidine-2(3H)-thione as selective adenosine A2A receptor antagonist

Discovery of 7-(Prolinol-N-yl)-2-phenylamino-thiazolo[5,4-d]pyrimidines as Novel Non-Nucleoside Partial Agonists for the A2A Adenosine Receptor: Prediction from Molecular Modeling

“…In the search of safe and selective drugs that regulate this receptor, a general concern is to achieve chemical novelty and good solubility values. Thiazolo­[5,4- d ]­pyrimidine is a bioisostere of purine in which the imidazole moiety is replaced by 1,3-thiazole. , Previous studies identified thiazolo­[5,4- d ]­pyrimidine derivatives as antagonists at adenosine A 2A receptors. − Using a computer-aided rational drug design approach, based on the A 2A AR crystal structures, we herein report the discovery and pharmacological characterization of 7-prolinol linked 2-phenylamino-thiazolopyrimidines as a new class of non-nucleoside A 2A AR partial agonists.…”