Novel adenovirus detected in kowari (Dasyuroides byrnei) with pneumonia

Gál, János; Mándoki, Míra; Sós, Endre; Kertész, Péter; Koroknai, Viktória; Bányai, Krisztiàn; Farkas, Szilvia L.

doi:10.1556/030.63.2016.024

Cited by 5 publications

(7 citation statements)

References 10 publications

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“…Unfortunately, blood was not immediately examined using microcopy or negative staining and by the time qPCR was carried out, the blood had been frozen and thawed multiple times. Viremia has been reported for other adenoviruses in pygmy marmosets ( Callithrix pygmaea ) ( 22 ), kowari ( Dasyuroides byrnei ) ( 23 ), sea lions ( Zalophus californianus ) ( 24 ), and reptiles ( 25 ). In these studies, adenoviral DNA was often isolated and amplified from several organs, even though the pathology did not always reflect a typical adenovirus infection, which is similar to what was observed with PbAdV-1.…”

Section: Discussionmentioning

confidence: 99%

Novel Divergent Polar Bear-Associated Mastadenovirus Recovered from a Deceased Juvenile Polar Bear

Dayaram

Tsangaras

Pavulraj

et al. 2018

mSphere

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Cross-species transmission of viral pathogens is becoming an increasing problem for captive-animal facilities. This study highlights how animals in captivity are vulnerable to novel opportunistic pathogens, many of which do not result in straightforward diagnosis from symptoms and histopathology. In this study, a novel pathogen was suspected to have contributed to the death of a juvenile polar bear. HTS techniques were employed, and a novel Mastadenovirus was isolated. The virus was present in both the tissue and blood samples. Phylogenetic analysis of the virus at both the gene and genome levels revealed that it is highly divergent to other known mastadenoviruses. Overall, this study shows that animals in isolated conditions still come into contact with novel pathogens, and for many of these pathogens, the host reservoir and mode of transmission are yet to be determined.

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Section: Discussionmentioning

confidence: 99%

Novel Divergent Polar Bear-Associated Mastadenovirus Recovered from a Deceased Juvenile Polar Bear

Dayaram

Tsangaras

Pavulraj

et al. 2018

mSphere

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“…Developed virus phylogeny using complete DNA-dependent DNA polymerase genes (Supplementary Figure S2) and host phylogeny based on cytochrome c oxidase subunit I gene sequences (Supplementary Figure S3) were used to generate tanglegram in Dendroscope (version 3.8.2, Free Software Foundation, Boston, MA, USA) [23]. Bootstrap network generated using SplitsTree 4.15.1 under 1000 replicates and partial DNA polymerase gene amino acid sequences (Supplementary Table S3) from representative adenoviruses [2,9,[16][17][18][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42], including adenovirus sequences reported in three recent independent studies [10,43,44]. In addition, an ML tree was generated using concatenated amino acid sequences of four major structural and functional genes: complete DNA-dependent DNA polymerase, penton, pTP and hexon.…”

Section: Phylogenetic Tree Construction and Evolutionary Analysesmentioning

confidence: 99%

“…Seeming less likely, it could represent a host switching event where the tropical screech owl was originally infected with a reptile virus. However, the mammalian clade (kowari) [27] amongst psittacine birds is a significant cross-species transmission of atadenoviruses rather than coevolution. The search for food and habitat sharing may provide the likely opportunities for atadenoviruses to switch their hosts.…”

Section: Commented [M11]mentioning

confidence: 99%

Adenoviruses in Avian Hosts: Recent Discoveries Shed New Light on Adenovirus Diversity and Evolution

Athukorala

Helbig

McSharry

et al. 2022

Viruses

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While adenoviruses cause infections in a wide range of vertebrates, members of the genus Atadenovirus, Siadenovirus, and Aviadenovirus predominantly infect avian hosts. Several recent studies on avian adenoviruses have encouraged us to re-visit previously proposed adenovirus evolutionary concepts. Complete genomes and partial DNA polymerase sequences of avian adenoviruses were extracted from NCBI and analysed using various software. Genomic analyses and constructed phylogenetic trees identified the atadenovirus origin from an Australian native passerine bird in contrast to the previously established reptilian origin. In addition, we demonstrated that the theories on higher AT content in atadenoviruses are no longer accurate and cannot be considered as a species demarcation criterion for the genus Atadenovirus. Phylogenetic reconstruction further emphasised the need to reconsider siadenovirus origin, and we recommend extended studies on avian adenoviruses in wild birds to provide finer evolutionary resolution.

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“…Among the predicted protein-coding ORFs of the PaAdV-1 genome, 24 were homologs to other AdVs gene products (Table 1). Among these homologues AdVs gene products, the highest number of protein-coding genes (21) in PaAdV-1 demonstrated homologs to the psittacine adenovirus-3 (PsAdV-3). The remaining three genes, encoding E1B-large T-antigen, E4, and a hypothetical protein (RH0, F-box related protein), were homologues to amniota adenovirus 1 (protein identity 25.26%, GenBank accession no.…”

Section: Genome Annotation and Comparative Analyses Of Paadv-1mentioning

confidence: 99%

“…Atadenoviruses have been detected in a diverse range of hosts, including birds [ 4 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ], reptiles (order Squamata; lizards, snakes, and worm lizards), ruminants [ 8 , 9 , 15 , 19 ], marsupials [ 20 , 21 ], and a common tortoise [ 22 ]. Using a partial DNA polymerase gene sequence, recent studies also report the presence of a large number of novel atadenoviruses circulating in wild passerine species of birds in Australia and Europe and passerine species kept in aviculture collections [ 4 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Characterisation of a Novel and Highly Divergent Passerine Adenovirus 1

Athukorala

Forwood

Phalen

et al. 2020

Viruses

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Wild birds harbour a large number of adenoviruses that remain uncharacterised with respect to their genomic organisation, diversity, and evolution within complex ecosystems. Here, we present the first complete genome sequence of an atadenovirus from a passerine bird that is tentatively named Passerine adenovirus 1 (PaAdV-1). The PaAdV-1 genome is 39,664 bp in length, which was the longest atadenovirus to be sequenced, to the best of our knowledge, and contained 42 putative genes. Its genome organisation was characteristic of the members of genus Atadenovirus; however, the novel PaAdV-1 genome was highly divergent and showed the highest sequence similarity with psittacine adenovirus-3 (55.58%). Importantly, PaAdV-1 complete genome was deemed to contain 17 predicted novel genes that were not present in any other adenoviruses sequenced to date, with several of these predicted novel genes encoding proteins that harbour transmembrane helices. Subsequent analysis of the novel PaAdV-1 genome positioned phylogenetically to a distinct sub-clade with all others sequenced atadenoviruses and did not show any obvious close evolutionary relationship. This study concluded that the PaAdV-1 complete genome described here is not closely related to any other adenovirus isolated from avian or other natural host species and that it should be considered a separate species.

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Novel adenovirus detected in kowari (Dasyuroides byrnei) with pneumonia

Cited by 5 publications

References 10 publications

Novel Divergent Polar Bear-Associated Mastadenovirus Recovered from a Deceased Juvenile Polar Bear

Novel Divergent Polar Bear-Associated Mastadenovirus Recovered from a Deceased Juvenile Polar Bear

Adenoviruses in Avian Hosts: Recent Discoveries Shed New Light on Adenovirus Diversity and Evolution

Molecular Characterisation of a Novel and Highly Divergent Passerine Adenovirus 1

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