Novel adenoviruses and herpesviruses detected in bats

Jánoska, Máté; Vidovszky, Márton Z.; Molnár, Viktor; Liptovszky, Mátyás; Harrach, Balázs; Benkő, Mária

doi:10.1016/j.tvjl.2010.06.020

Cited by 68 publications

(55 citation statements)

References 10 publications

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“…These viruses share several homologous genes in their E3 and E4 regions that are usually type specific in AdVs (Davison et al, 2003;Ursu et al, 2004). The phylogenetic clustering further supported the presumptive close common ancestry of CAdVs and certain vespertilionid BtAdVs (Jánoska et al, 2011;Benkő et al, 2014). In the present work, a newly found sequence from a putative bat AdV, named tentatively as vespertilionid AdV-4, appeared right between CAdV-1 and -2 implying its affiliation to the virus species Canine mastadenovirus A (Fig.…”

Section: Discussionsupporting

confidence: 76%

“…In a quest for the biodiversity represented by adenoviruses, we started to examine bats hoping for the discovery of numerous novel types and variants. Indeed, the results of our very first surveys, demonstrating a rather high (28.5%) prevalence of AdVs in bat samples in Hungary, have verified this expectation (Jánoska et al, 2011;Vidovszky and Boldogh, 2011). During the short period of half a decade, more than two dozens of novel AdV sequences have been reported from representatives of different bat species from Europe, Asia and America.…”

Section: Discussionsupporting

confidence: 58%

“…This PCR was successful from 21 samples only, including 11 German and 10 Hungarian ones from bats of 14 species (Table 1). We also PCR-amplified and sequenced this gene fragment from four putative bat AdVs that had been detected and described in our laboratory before (Jánoska et al, 2011;Vidovszky and Boldogh, 2011). All IVa2 sequences seemed to be homogeneous, even those which were obtained from three samples that contained multiple, albeit just slightly diverging, pol sequences.…”

Section: Diversity and Emerging Host Range Of The Newly Detected Bat mentioning

confidence: 99%

“…In the past few years, bats have emerged as an especially rich source of novel viruses, including AdVs (Jánoska et al, 2011;Vidovszky and Boldogh, 2011).…”

mentioning

confidence: 99%

“…From this strain (isolate 1050597), short partial sequences of the pol and hexon genes were published (Raut et al, 2012). Besides these four AdV isolates, partial sequences obtained by PCR and viral metagenomics from about twenty further bat AdVs have been published in the USA, China, Germany, Hungary, and Brazil (Li et al, 2010a;Li et al, 2010b;Drexler et al, 2011;Jánoska et al, 2011;Vidovszky and Boldogh, 2011;Lima et al, 2013;Yang et al, 2013). Moreover, a collection of partial pol sequences, obtained from AdVs of different bats in Spain, has been deposited to the GenBank (Casas et al, 2010).…”

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confidence: 99%

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Random sampling of the Central European bat fauna reveals the existence of numerous hitherto unknown adenoviruses

Vidovszky

Kohl

Boldogh

et al. 2015

Acta Veterinaria Hungarica

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From over 1250 extant species of the order Chiroptera, 25 and 28 are known to occur in Germany and Hungary, respectively. Close to 350 samples originating from 28 bat species (17 from Germany, 27 from Hungary) were screened for the presence of adenoviruses (AdVs) using a nested PCR that targets the DNA polymerase gene of AdVs. An additional PCR was designed and applied to amplify a fragment from the gene encoding the IVa2 protein of mastadenoviruses. All German samples originated from organs of bats found moribund or dead. The Hungarian samples were excrements collected from colonies of known bat species, throat or rectal swab samples, taken from live individuals that had been captured for faunistic surveys and migration studies, as well as internal organs of dead specimens. Overall, 51 samples (14.73%) were found positive. We detected 28 seemingly novel and six previously described bat AdVs by sequencing the PCR products. The positivity rate was the highest among the guano samples of bat colonies. In phylogeny reconstructions, the AdVs detected in bats clustered roughly, but not perfectly, according to the hosts' families (Vespertilionidae, Rhinolophidae, Hipposideridae, Phyllostomidae and Pteropodidae). In a few cases, identical sequences were derived from animals of closely related species. On the other hand, some bat species proved to harbour more than one type of AdV. The high prevalence of infection and the large number of chiropteran species worldwide make us hypothesise that hundreds of different yet unknown AdV types might circulate in bats.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 58%

Section: Diversity and Emerging Host Range Of The Newly Detected Bat mentioning

confidence: 99%

“…In the past few years, bats have emerged as an especially rich source of novel viruses, including AdVs (Jánoska et al, 2011;Vidovszky and Boldogh, 2011).…”

mentioning

confidence: 99%