Novel AIEgen-Functionalized Diselenide-Crosslinked Polymer Gels as Fluorescent Probes and Drug Release Carriers

Zhao, Jie; Pan, Xiangqiang; Zhu, Jian; Zhu, Xiulin

doi:10.3390/polym12030551

Cited by 20 publications

(9 citation statements)

References 43 publications

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“…Since the redox process is faster in tumor cells, the drug release is explained well under redox conditions as the polymeric gel is well utilized as diselenide bond cleavage takes place for redox stimulus in the tumor environment. Hence, the SeSe y -PAA-TPE x can be used for loading and release [ 154 ]. Recently, Li and group constructed and fabricated nanoparticles using a self-assembled strategy.…”

Section: Aie Molecules For Drug Delivery Systemsmentioning

confidence: 99%

Recent Advances in Aggregation-Induced Emission Active Materials for Sensing of Biologically Important Molecules and Drug Delivery System

et al. 2021

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The emergence and development of aggregation induced emission (AIE) have attracted worldwide attention due to its unique photophysical phenomenon and for removing the obstacle of aggregation-caused quenching (ACQ) which is the most detrimental process thereby making AIE an important and promising aspect in various fields of fluorescent material, sensing, bioimaging, optoelectronics, drug delivery system, and theranostics. In this review, we have discussed insights and explored recent advances that are being made in AIE active materials and their application in sensing, biological cell imaging, and drug delivery systems, and, furthermore, we explored AIE active fluorescent material as a building block in supramolecular chemistry. Herein, we focus on various AIE active molecules such as tetraphenylethylene, AIE-active polymer, quantum dots, AIE active metal-organic framework and triphenylamine, not only in terms of their synthetic routes but also we outline their applications. Finally, we summarize our view of the construction and application of AIE-active molecules, which thus inspiring young researchers to explore new ideas, innovations, and develop the field of supramolecular chemistry in years to come.

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Section: Aie Molecules For Drug Delivery Systemsmentioning

confidence: 99%

Recent Advances in Aggregation-Induced Emission Active Materials for Sensing of Biologically Important Molecules and Drug Delivery System

et al. 2021

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“…In comparison with traditional FPs, AIE polymers present the advantages of high PL efficiency in aggregate and solid states, a large Stokes shift, outstanding photostability, etc. Thus, AIE polymers are expected to exhibit unique properties and remarkable advantages in their practical applications [ 51 , 59 , 60 ]. Furthermore, the structure, composition, and morphology of AIE polymers can be fine-tuned to meet the diverse needs of practical applications in chemo/biosensing, imaging, and theranostics.…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Polymers Conspectus

Ahumada

Borkowska

2022

Polymers

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The development of luminescent materials is critical to humankind. The Nobel Prizes awarded in 2008 and 2010 for research on the development of green fluorescent proteins and super-resolved fluorescence imaging are proof of this (2014). Fluorescent probes, smart polymer machines, fluorescent chemosensors, fluorescence molecular thermometers, fluorescent imaging, drug delivery carriers, and other applications make fluorescent polymers (FPs) exciting materials. Two major branches can be distinguished in the field: (1) macromolecules with fluorophores in their structure and (2) aggregation-induced emission (AIE) FPs. In the first, the polymer (which may be conjugated) contains a fluorophore, conferring photoluminescent properties to the final material, offering tunable structures, robust mechanical properties, and low detection limits in sensing applications when compared to small-molecule or inorganic luminescent materials. In the latter, AIE FPs use a novel mode of fluorescence dependent on the aggregation state. AIE FP intra- and intermolecular interactions confer synergistic effects, improving their properties and performance over small molecules aggregation-induced, emission-based fluorescent materials (AIEgens). Despite their outstanding advantages (over classic polymers) of high emission efficiency, signal amplification, good processability, and multiple functionalization, AIE polymers have received less attention. This review examines some of the most significant advances in the broad field of FPs over the last six years, concluding with a general outlook and discussion of future challenges to promote advancements in these promising materials that can serve as a springboard for future innovation in the field.

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“…Selenium-containing polymers have received increasing attention in various promising applications including high refractive index materials, dynamic covalent bond materials, drug delivery materials, antibacterial materials, and stimulus responsive materials. [1][2][3][4][5][6][7][8][9][10][11][12] The most important chemical property for selenium-containing polymers is redox responsiveness, for example, the selenide moiety in the polymer can be oxidized to form selenoxide or selenone groups [13][14][15][16] and even eliminated by oxidants. [17,18] Based on phenylseleno oxidation elimination, DOI: 10.1002/macp.202100351 it's easy to prepare functional materials with carbon-carbon (C-C) double bonds.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Precisely Structured Olefin Copolymers by Phenylseleno Oxidation Elimination

Liu

et al. 2021

Macro Chemistry & Physics

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Selenium-containing polymers have attracted considerable attention due to their unique redox responsiveness. Here, phenyl vinyl selenide (PVSe), as a functional selenium-containing monomer, is polymerized with maleimide (MI) or its derivatives by reversible addition-fragmentation chain transfer polymerization. The resulting polymers are characterized by matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy and proton nuclear magnetic resonance spectra, which particularly prove the obtaining of alternating polymers through the polymerization of PVSe and MI or its derivatives. Properties of the resulting polymers are systematically investigated, such as glass transition temperature, thermal performance, and refractive indices. What's more, based on phenylseleno oxidation elimination, the alternating polymers are oxidized through 30% H 2 O 2 to form precisely structured olefin copolymers with carbon-carbon (C-C) double bonds. The selective generation of double bonds in the alternating polymers is systematically studied. The efficiency of such oxidation is very high under mild conditions due to low electronegativity and bond energy of carbon-selenium (C-Se) bond, which provides a novel method to prepare precisely structured olefin copolymers with MI or its derivatives.

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Novel AIEgen-Functionalized Diselenide-Crosslinked Polymer Gels as Fluorescent Probes and Drug Release Carriers

Cited by 20 publications

References 43 publications

Recent Advances in Aggregation-Induced Emission Active Materials for Sensing of Biologically Important Molecules and Drug Delivery System

Recent Advances in Aggregation-Induced Emission Active Materials for Sensing of Biologically Important Molecules and Drug Delivery System

Fluorescent Polymers Conspectus

Synthesis of Precisely Structured Olefin Copolymers by Phenylseleno Oxidation Elimination

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