Novel alleles HLA‐B*7802 and B*51022: evidence for convergency in the HLA‐B5 family

Prilliman, Kiley R.; Steiner, Noriko; Ellexson, Mary; Stewart, Dod; Lau, Marie; Terasaki, Paul I.; Hurley, Carolyn Katovich; Hildebrand, William H.

doi:10.1111/j.1399-0039.1996.tb02513.x

Cited by 8 publications

(4 citation statements)

References 35 publications

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“…The major peptide motifs of B*3905, that is His2 and Leu9, are also found in a few other HLA-B allotypes: B*3901, B*3909, B*1509, B*1510, and B*3801 (24,18,25). Of the 25 peptides sequenced from B*3905, 6 (24%) were previously sequenced from B*3901 (18)(19)(20), 3 (12%) from B*3909 (19,20), 2 (8%) from B*3801 (18), 4 (16%) from B*1509 (24), and 1 (4%) from B*1510 (25). Due to the limited number of peptides sequenced from any one allotype the percent sharing observed is probably a minimum one.…”

Section: Discussionmentioning

confidence: 91%

Peptide specificity of the Amerindian B*3905 allotype: molecular insight into selection mechanisms driving HLA class I evolution in indigenous populations of the Americas

et al. 2000

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HLA-B*3905 is apparently restricted to Amerindian populations and presents a wide geographical distribution, from Mexico to Argentina. It differs from B*3901, one of the founder HLA class I alleles of Central and South Amerindians, by a single nucleotide substitution leading to an Asp74Tyr change in the gene product. The peptide specificity of the B*3905 protein was characterized by pool sequence analysis of B*3905-bound peptides and by sequencing of a set of individual ligands, using electrospray ion trap mass spectrometry. The results indicate a double effect of the B*3905 mutation. First, pocket B specificity was shifted towards an increased preference for His at peptide position 2, which is the main anchor for B39-bound peptides, relative to B*3901. Second, at peptide position 3 acidic residues were favored, and aromatic residues disfavored, relative to B*3901. These features approach the peptide specificity of B*3905 to B*3801 and B*1509, allotypes absent from Central and South Amerindians. Together with B*3909, B*3905 is the second HLA-B39 subtype whose polymorphism results in a shift of peptide specificity towards that of HLA-B allotypes absent from these populations. This suggests that HLA-B39 evolution in Central and South America may be an antigen-driven adaptive response, leading to generate antigen-presenting properties absent from the HLA class I repertoire of the ancestral population.

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Section: Discussionmentioning

confidence: 91%

Peptide specificity of the Amerindian B*3905 allotype: molecular insight into selection mechanisms driving HLA class I evolution in indigenous populations of the Americas

et al. 2000

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“…The high frequency of B*5301 supports the idea that alleles can be positively selected under pathogenic pressure (19). HLA‐B78 was previously thought to be African restricted (12, 20), but recent studies have shown that subtypes of this antigen are found in native Americans, caucasians, Hispanics and Orientals as well (18, 21–24).…”

mentioning

confidence: 99%

Sequence analysis of exons 1, 2, 3, 4 and 5 of the HLA‐B5/35 cross‐reacting group

2002

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The HLA-B5/35 cross-reacting group (CREG) is a set of closely related antigens including HLA-B35, B51, B52, B53 and B78. The nucleotide sequences of exon 1 through 5 of the B5/35 CREG were determined to assess the level of polymorphism. For exons 2 and 3, the previously described sequence-based typing (SBT) strategy was applied, the nucleotide sequences of exon 1, 4 and 5 were determined by allele-specific sequencing. A total of 225 unrelated individuals were HLA-B typed by heterozygous sequencing of exons 2 and 3. In the B5/35 CREG, 26 different alleles were identified, whereas 63 non-B5/35 CREG alleles were sequenced. The SBT strategy was proven to be reliable and efficient for high resolution typing of the B5/35 CREG. The nucleotide sequences of exon 1, 4 and 5 were determined for the 26 different B5/35 CREG alleles to establish the level of polymorphism. For seven different alleles, of which the exon 1, 4 and 5 sequences were hitherto unknown, the sequences were elucidated and in agreement with the known B5/35 sequences. Nineteen HLA-B5/35 CREG alleles with previously published exon 1, 4 and 5 sequences were sequenced in at least two individuals. Three new alleles were identified. The first, B*5204, showed a difference at position 200 compared to B*52011, which was previously considered a conserved position. The other two alleles, B*3542 and B*51015, showed exon 2 and 3 sequences identical to B*35011 and B*51011, but differences in exons 1 and 4, respectively. B*3542 had differences at position 25 and 72 and B*51015 showed a difference at position 636. More polymorphism might be present outside exons 2 and 3 than previously thought.

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“…Similar nucleotide substitutions have been reported between B*53 and B*35 (11) or B*38 and B*39 (12). Based on the previously described hypothesis (4, 13), it is likely that B*7805 is formed from B*52011 by a gene conversion from Bw4 to Bw6 in the coding region defining Bw4/6. HLA‐B52 is a common class I antigen in various ethnic groups and its high frequencies are observed in Japanese (10.7%) (14), whereas the allele frequency of B*78 is very rare in Japanese and geographically localized in Senegale (5.2%), West Africa (1.4%), Kazakhstan (0.8%) (14) and Venezuela (0.022%) (15).…”

Section: Pcr and Sequencing Primers In This Studymentioning

confidence: 94%

“…The first B78 allele was B*7801 found in Moroccans as B’SNA’ (1, 2). While B*7801 was associated with black populations (3), B*78021 (4), B*78022 (5) and B*7803 (C. Hurley, unpublished data) have been identified in Caucasian populations, and recently B*7804 has been detected in Hispanic populations (6).…”

Section: Pcr and Sequencing Primers In This Studymentioning

confidence: 99%

Identification of a novel allele HLA‐B*7805 in a Japanese female

Sekimoto¹,

Araseki²,

Sato³

et al. 2001

Tissue Antigens

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A new HLA-B*78 allele, B*7805, was identified in a healthy Japanese female. The results of her serological HLA class I typing showed an unusual Bw4/Bw6 pattern with strongly positive reactivity to anti-Bw6, i.e. A24, -, B52, -, Bw4, Bw6. In DNA typing, she was typed as A*24, -, B*52, B*78-like, Cw1202, -, (Bw4, Bw6). Cloning and sequencing of exon 2 and exon 3 of her B locus genes revealed a new allele B*7805. The cloned B*7805 differed from B*78021 by three nucleotide substitutions in exon 2 at position 259 (A to G), 261 (C to G) and 272 (A to C), and contained sequences defining Bw6 motif in the region of codon 77 to 83.

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Novel alleles HLA‐B7802 and B51022: evidence for convergency in the HLA‐B5 family

Cited by 8 publications

References 35 publications

Peptide specificity of the Amerindian B*3905 allotype: molecular insight into selection mechanisms driving HLA class I evolution in indigenous populations of the Americas

Peptide specificity of the Amerindian B*3905 allotype: molecular insight into selection mechanisms driving HLA class I evolution in indigenous populations of the Americas

Sequence analysis of exons 1, 2, 3, 4 and 5 of the HLA‐B5/35 cross‐reacting group

Identification of a novel allele HLA‐B*7805 in a Japanese female

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