Novel and established anthropometric measures and the prediction of incident cardiovascular disease: a cohort study

Carlsson, Axel C.; Risérus, Ulf; Engström, Gunnar; Ärnlöv, Johan; Melander, Olle; Leander, Karin; Gigante, Bruna; Hellénius, M.-L.; Fairé, Ulf dé

doi:10.1038/ijo.2013.46

Cited by 48 publications

(52 citation statements)

References 37 publications

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“…For skewed variables, the Wilcoxon-Mann-Whitney test was used to assess differences between sexes, 26 whereas differences in frequencies of baseline characteristics were assessed by χ 2 tests. For variables with normal distribution, sex differences in means were evaluated by a 2-tailed Student t test.…”

Section: Discussionmentioning

confidence: 99%

Polyunsaturated Fat Intake Estimated by Circulating Biomarkers and Risk of Cardiovascular Disease and All-Cause Mortality in a Population-Based Cohort of 60-Year-Old Men and Women

et al. 2015

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Background-High intake of polyunsaturated fatty acids (PUFAs) may reduce the risk of cardiovascular disease (CVD) and mortality. Large, prospective studies including both sexes and circulating PUFAs as dietary biomarkers are needed. We investigated sex-specific associations of the major dietary PUFAs, eicosapentaenoic acid, docohexaenoic acid, linoleic acid, and α-linolenic acid, with incident CVD and all-cause mortality in a population-based cohort. Methods and Results-PUFAs in serum cholesterol esters were measured at baseline in 60-year-old Swedish women (n=2193) and men (n=2039). With the use of national registers, 484 incident CVD events (294 men and 190 women) and 456 all-cause deaths (265 men and 191 women) were identified during follow-up (median, 14.5 years) in individuals without prior CVD at baseline. Associations of PUFAs with CVD and mortality were evaluated with Cox proportional hazard models. In multivariable-adjusted models, 1-SD increases in eicosapentaenoic acid and docohexaenoic acid were associated with lower risk of incident CVD among women (hazard ratio PUFAs seem to have selective roles in the development of CVD, whereas possible influences on non-CVD outcomes are less clear. 9 Dietary intake of EPA, DHA, LA, and, to a lesser extent, ALA is reflected in the FA composition in serum cholesteryl esters (CEs); thus, the proportions of these PUFAs in CEs can be used as biomarkers to assess the intake of the respective PUFA.[10-12 Accordingly, FA composition (especially EPA, DHA, and LA) in CEs correlates well with self-reported FA intake in both Swedish 13 and other cohorts.14 Several prospective cohort and nested case-control studies have used serum CE FAs as a biomarker of dietary fat and investigated possible relationships with risks of all-cause and CVD mortality, 15 fatal coronary heart disease (CHD), 16 and incidences of CHD, 17 heart failure, 18 and stroke. 19,20 Among middle-aged Swedish men, a 1-SD increase (5.2%) in serum CE LA was associated with 13% and 15% lower risk of all-cause and CVD mortality, respectively, whereas no significant associations were observed for serum CE EPA, DHA, or ALA. In addition, a recent meta-analysis suggested that CE LA is associated with a lower risk of fatal CHD, whereas no such associations have been observed for n-3 PUFAs. 16 However, previous studies investigating relationships between serum CE PUFAs and CVD-related outcomes have included predominantly men, although men and women may differ in CVD risks and mortality. 21 Thus, identification of possible sex-specific associations might have been hampered by the limited number of women.Furthermore, recent studies have reported inverse associations of both n-6 and n-3 PUFAs in plasma phospholipid with all-cause and cause-specific mortality and with incident CVD in a US cohort of older men and women. 22,23 This study investigated associations between biomarkers of PUFA intake (EPA, DHA, LA, and ALA) in serum CEs and incident CVD and all-cause mortality in men and women, separately and combined, in a ...

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Section: Discussionmentioning

confidence: 99%

Polyunsaturated Fat Intake Estimated by Circulating Biomarkers and Risk of Cardiovascular Disease and All-Cause Mortality in a Population-Based Cohort of 60-Year-Old Men and Women

et al. 2015

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“…Baseline examinations were performed between 1991 and 1994 [9]. Plasma IL8 and genotype data were available in 700 individuals and in close to 800 individuals with metabolic syndrome (we have merged the data for those with repeated measurements N = 1218).…”

Section: Study Populationsmentioning

confidence: 99%

Duffy antigen receptor genetic variant and the association with Interleukin 8 levels

et al. 2015

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“…An additional confounding factor was that non-parametric correlations were not significant for NRS-2002, while those for the unintentional loss of weight were found to have slightly inverse values, which were not significant in ROC analyses. Reproducibility of decreased LVMM in patients with increased nutritional risk could be furthermore limited due to differences in anthropometrics between the groups [22,23] . Patients with increased nutritional risk were of a significantly lesser weight, which was also seen in BMI and WCs, where the last 2 were also significantly correlated with the left ventricle mass estimated by Devereux formula.…”

Section: Discussionmentioning

confidence: 99%

Influence of Transiently Increased Nutritional Risk on a Left Ventricle Myocardial Mass Assessed by Echocardiography

Boban

Laviano

Peršić³

et al. 2016

Ann Nutr Metab

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Background/Aim: Metabolic derangements due to increased nutritional risk lead to catabolism and loss of proteins, muscle tissue and eventually mass of parenchymatous organs. The aim of our study was to assess whether transitory nutritional risk after heart surgery influences on the left ventricle myocardial mass (LVMM), assessed by echocardiography. Methods: Consecutive sample of patients scheduled for cardiovascular rehabilitation, in period 0-3 months after surgery. Nutritional risk screening (NRS) was analyzed using the NRS-2002 tool. Results: Study sample included 330 patients after heart surgery for ischemic 186 (56.4%); valvular 91 (27.6%) and valvular plus ischemic 53 (16.1%) heart disease. Age was 65.5 ± 10.6 (range 23-84) and there were more male patients than female - 240 (72.7%) and 90 (27.3%), respectively. The percentage of unintentional loss of weight was 10.8 ± 3.4%, in range 0-23.81%, whereas NRS-2002 was 4.4 ± 1.1. LVMM was 218.7 ± 65.9 g vs. 252.3 ± 51.7 (p = 0.015); for patients with increased nutritional risk and controls, respectively. There was no significant correlation of LVMM with NRS-2002, while the percentage of unintentional loss of weight displayed only weakly inverse correlation (Rho CC = -0.197; p = 0.007). LVMM also correlated significantly with body mass index (Rho CC = 0.247; p < 0.001) and waist-to-hip ratio (Rho CC = 0.291; p < 0.001). In conclusion, LVMM was found to decrease slightly in the period of increased nutritional risk, following heart surgery. Changes in LVMM are partially consequences of systemic catabolic response, as well as anthropometric changes due to unintentional loss of weight.

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Novel and established anthropometric measures and the prediction of incident cardiovascular disease: a cohort study

Abstract: WHHR, a new measure reflecting body fat distribution, showed the highest risk estimates after adjustments for established CVD risk factors. These findings were verified in men but not women in an independent cohort.

Cited by 48 publications

References 37 publications

Polyunsaturated Fat Intake Estimated by Circulating Biomarkers and Risk of Cardiovascular Disease and All-Cause Mortality in a Population-Based Cohort of 60-Year-Old Men and Women

Polyunsaturated Fat Intake Estimated by Circulating Biomarkers and Risk of Cardiovascular Disease and All-Cause Mortality in a Population-Based Cohort of 60-Year-Old Men and Women

Duffy antigen receptor genetic variant and the association with Interleukin 8 levels

Influence of Transiently Increased Nutritional Risk on a Left Ventricle Myocardial Mass Assessed by Echocardiography

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