Novel and robust treatment of pulmonary hypertension with netrin-1 and netrin-1-derived small peptides

Murugesan, Priya; Zhang, Yixuan; Youn, Ji Youn; Cai, Hua

doi:10.1016/j.redox.2022.102348

Cited by 7 publications

(2 citation statements)

References 47 publications

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“…CD38 inhibits SIRT3 expression and activates of Ca 2+ -NFAT, playing an essential role in cardiac hypertrophy [25]. Vascular remodeling mediated by NO deficiency and oxidative stress plays a vital role in the pathogenesis of PH, and the total superoxide production and eNOS uncoupling activity induced by hypoxia could be attenuated through netrin-1 and netrin-1 derived small peptides [26]. Oxidative stress-induced myocardial injury and dysfunction can be alleviated by inhibition the calpain of mitochondria in cardiac pathologies, which is an effective strategy [27].…”

Section: Discussionmentioning

confidence: 99%

Hypoxia-Induced Cardiomyocyte Apoptosis Exacerbates Cardiomyocyte Hypertrophy and Myocardial Injury through p38 MAPK Pathway in SD Rats

Li¹,

Pu²,

Xu³

et al. 2023

Preprint

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Right ventricular remodeling and its function are closely related to the symptom severity and survival of hypoxia pulmonary hypertension, but molecular mechanisms of cardiomyocyte hypertrophy and myocardial injury remain unclear. It evaluated the cardiac function (by right cardiac catheterization to measure right ventricular systolic pressure and mean pulmonary artery pressure), myocardial tissue morphology（Haematoxylin and Eosin）, myocardial hypertrophy (Wheat Germ Agglutinin Staining), then RNA sequencing was applied to explore the mechanism, which results were verified by western blot in final. Hypoxia developed pulmonary hypertension, right ventricular diastolic and systolic functions were enhanced in rats, such as the mean pulmonary artery pressure, systolic pressure of pulmonary artery, the max pressure of right ventricular, the mean right ventricular pressure, and the heart rate was significantly higher than that in control. We found that Hif-1 signaling pathway and p38-MAPK signaling pathway have been activated by hypoxia, and cardiomyocyte apoptosis also aggravated in the right ventricular, which might be one cause of cardiomyocyte hypertrophy and myocardial injury, and targeted intervention might be one potential prevention for cardiomyocyte hypertrophy and myocardial injury induced by hypoxia.

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Section: Discussionmentioning

confidence: 99%

Hypoxia-Induced Cardiomyocyte Apoptosis Exacerbates Cardiomyocyte Hypertrophy and Myocardial Injury through p38 MAPK Pathway in SD Rats

Li¹,

Pu²,

Xu³

et al. 2023

Preprint

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“…Owing to the proved intestinal barrier permeability [ 25 ], GSNO is a good candidate for oral administration to treat diseases related to NO deficiency (e.g., atherosclerosis, pulmonary hypertension, thrombosis, ischemia [ 26 , 27 , 28 , 29 ]). Zhou et al reported three types of Eudragit ® polymer particles with a similar encapsulation efficiency (around 30%): nanoparticles (NPs) (0.225 ± 0.003 μm) and microparticles (MPs) (69 ± 7 μm) prepared by a water-in-oil-in-water (W/O/W) double emulsion-evaporation process versus microparticles (165 ± 14 μm) prepared by a solid-in-oil-in-water (S/O/W) emulsion/evaporation process [ 24 ].…”

Section: Direct Gsno Loaded Nano/micro-formulationmentioning

confidence: 99%

A Mini Review of S-Nitrosoglutathione Loaded Nano/Micro-Formulation Strategies

Hui

Zhang

et al. 2023

Nanomaterials

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As a potential therapeutic agent, the clinical application of S-nitrosoglutathione (GSNO) is limited because of its instability. Therefore, different formulations have been developed to protect GSNO from degradation, delivery and the release of GSNO at a physiological concentration in the active position. Due to the high water-solubility and small molecular-size of GSNO, the biggest challenges in the encapsulation step are low encapsulation efficiency and burst release. This review summarizes the different nano/micro-formulation strategies of a GSNO related delivery system to provide references for subsequent researchers interested in GSNO encapsulation.

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