Novel and simple route to fabricate fully biocompatible plasmonic mushroom arrays adhered on silk biopolymer

Abstract

A fully biocompatible plasmonic quasi-3D nanostructure is demonstrated by a simple and reliable fabrication method using strong adhesion between gold and silk fibroin. The quasi-3D nature gives rise to complex photonic responses in reflectance that are prospectively useful in bio/chemical sensing applications. Laser interference lithography is utilized to fabricate large-area plasmonic nanostructures.

A fully biocompatible poly(ethylene glycol)–gold plasmonic crystal for optical sensing

“…Since noble metals used for plasmonic applications are basically biocompatible, it can open up an avenue to realizing a fully biocompatible plasmonic bio-device when used in conjunction with biopolymers [16]. To date, the conventional approach to demonstrating plasmonic devices is through the integration of metallic nanostructures onto silicon, glass, and polydimethylsiloxane (PDMS), which have poor biointerfaces and functional programmabilities [17].…”

Interacting Metal–Insulator–Metal Resonator by Nanoporous Silver and Silk Protein Nanomembranes and Its Water-Sensing Application

“…4,17,20,21 In addition, composites of noble metals and silk nanostructures impart biocompatibility and a strong optical response. 4,22−24 Facile intermolecular cross-linking by water vapor or organic solvent treatment creates nanochannels in the hydrogel, and these nanochannels facilitate the detection and quantification of the analytes in aqueous solutions. 4,22−24 Furthermore, the hydratable silk hydrogel allows the interaction of the photonic device with various body fluids in vivo, making these devices ideal candidates for epidermal and human-implantable applications.…”

“…4,22−24 Facile intermolecular cross-linking by water vapor or organic solvent treatment creates nanochannels in the hydrogel, and these nanochannels facilitate the detection and quantification of the analytes in aqueous solutions. 4,22−24 Furthermore, the hydratable silk hydrogel allows the interaction of the photonic device with various body fluids in vivo, making these devices ideal candidates for epidermal and human-implantable applications. 25 The properties of silk make it suitable as the dielectric layer in MIM-based sensors for translating the chemical signal to the optical resonance depending on the operating environment.…”

Controllable gold-capped nanoporous anodic alumina chip for label-free, specific detection of bacterial cells

“…Several plasmonic nanostructures have been developed, including coupled nanoparticle arrays, periodic or random nanohole arrays, gold-capped mushroom arrays, and arrays of nanoimprinted nanodisks or nanosquares. [2][3][4][5][6][7][8][9][10] Of these nanostructures, gold-coated nanostructured porous anodic alumina (PAA) has been found to exhibit enhanced optical properties through the combination of two sensing approaches, namely localized surface plasmon resonance (LSPR) spectroscopy and interferometry. [11][12][13][14][15][16] Nanostructured PAA is composed of an alumina lattice template with periodic nanopores of uniform size and a regular diameter along their length.…”