2012
DOI: 10.2174/138945012799499703
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Novel and Viable Acetylcholinesterase Target Site for Developing Effective and Environmentally Safe Insecticides

Abstract: Insect pests are responsible for human suffering and financial losses worldwide. New and environmentally safe insecticides are urgently needed to cope with these serious problems. Resistance to current insecticides has resulted in a resurgence of insect pests, and growing concerns about insecticide toxicity to humans discourage the use of insecticides for pest control. The small market for insecticides has hampered insecticide development; however, advances in genomics and structural genomics offer new opportu… Show more

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Cited by 61 publications
(72 citation statements)
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“…It is now clear that D. melanogaster has only one Ace gene as confirmed by its genome sequence [11], whereas most other insect species have two different Ace genes ( i.e. , Ace1 and Ace2 ) [12]. Ace1 commonly refers to the Ace paralogous (AP- Ace ) gene and Ace2 the Ace orthologous (AO- Ace ) gene in relation to the D. melanogaster Ace [8].…”
Section: Introductionmentioning
confidence: 99%
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“…It is now clear that D. melanogaster has only one Ace gene as confirmed by its genome sequence [11], whereas most other insect species have two different Ace genes ( i.e. , Ace1 and Ace2 ) [12]. Ace1 commonly refers to the Ace paralogous (AP- Ace ) gene and Ace2 the Ace orthologous (AO- Ace ) gene in relation to the D. melanogaster Ace [8].…”
Section: Introductionmentioning
confidence: 99%
“…The existence of two Ace genes in insects has attracted much attention to the study of their functions, particularly their roles in insecticide resistance [8], [32] and as targets for developing new insecticides [12], [33]–[37]. Beetles (coleopterans) are the most evolutionarily successful metazoans, accounting for 25% of all known animal species, far more than any other taxonomic orders [31].…”
Section: Introductionmentioning
confidence: 99%
“…Insecticide resistance has also been shown to be a problem in S. frugiperda control even in areas where the new technologies based on Bt plants were implemented (Storer et al 2010). Because of all of these issues, there is a continuous need for the search of alternative strategies for pest control or for the discovery of new molecules with insecticidal potential that would be environmental friendly and less noxious to the non-target species (Casida & Quistad 1998, Pang et al 2012.…”
Section: Introductionmentioning
confidence: 99%
“…Interestingly, disease-transmitting mosquitoes such as the African malaria mosquito ( Anopheles gambiae sensu stricto) and the common house mosquito ( Culex pipiens L.) have two AChEs—Ace-paralogous AChE (AP-AChE) and Ace-orthologous AChE—both of which have an insect-specific cysteine residue near its active site11. Responsible for cholinergic functions121314, AP-AChE has an insect-specific cysteine located at the rim of its active site11.…”
mentioning
confidence: 99%