Novel Anti-Inflammatory Effects of Brimonidine on <i>Propionibacterium acnes</i>-Induced Inflammatory Reaction

Choi, So Ra; Yoo, Jin Gwi; Kim, Soo Jung; Choi, Chong Won; Lee, Young; Kim, Chang Deok; Seo, Young Joon; Lee, Jeung Hoon; Im, Myung; Park, Kyung Duck

doi:10.5021/ad.2020.32.4.342

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Furthermore, some studies reported that seaweed also shows good antimicrobial properties. Based on a study conducted by Choi et al [29], seaweed does show strong antibacterial activity against C. acnes and also has anti-inflammatory properties. Seaweed has also been reported to have an effective antibacterial effect against S. aureus [30].…”

Section: Mic Mbc and Mbc/mic Ratio Of Dr Ridz Anti-acne Nanoserum®mentioning

confidence: 99%

Antibacterial Activity of Dr. Ridz Anti-Acne Nanoserum® Against Skin Bacteria That Cause Acne Vulgaris

Ridzuan,

Noraziah,

et al. 2024

Jurnal Teknologi

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Cutibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus are commonly associated with the pathogenesis of acne vulgaris. Skincare products that contain natural ingredients have become a trend to treat acne. Dr.Ridz Anti-Acne Nanoserum® product was formulated with the extract of Cassia alata leaf and Piper betle. The aim of this study was to determine the antibacterial activity of this formulated product against against C. acnes, S. epidermidis, and S. aureus. The minimum inhibitory concentration (MIC) value and the minimum bactericidal concentration (MBC) were determined using a broth microdilution and a streak plate method, respectively. The rate of killing by this product was tested using time-kill assay (TKA) at 0.5x MIC, 1x MIC, and 2x MIC with incubation periods of 2, 4, 6, 8 10, 12, and 24 hours. The MIC values showed that this product inhibited S. epidermidis and S. aureus better than C. acnes. From the calculation of the MBC/MIC ratio, this product showed bactericidal effects against all tested bacteria. The time-kill studies showed that the killing effect of this product was concentration-dependent, and the highest antibacterial activity was observed at the concentration of 2x MIC against all tested bacteria. In conclusion, Dr.Ridz Anti-Acne Nanoserum® exhibits the best antibacterial activities against S. epidermidis and showed a bactericidal effect towards all tested bacteria. .

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Section: Mic Mbc and Mbc/mic Ratio Of Dr Ridz Anti-acne Nanoserum®mentioning

confidence: 99%

Antibacterial Activity of Dr. Ridz Anti-Acne Nanoserum® Against Skin Bacteria That Cause Acne Vulgaris

Ridzuan,

Noraziah,

et al. 2024

Jurnal Teknologi

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Novel Uses of Brimonidine

Kruthika,

Tulika,

Sagarika

et al. 2024

Delhi Journal of Ophthalmology

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Brimonidine tartrate is a third-generation, highly selective alpha 2 agonist currently available in various formulations and doses to treat ophthalmological conditions. The aim of this article was to review pharmacokinetics, mechanisms, side effects, and updates on clinical use of topical brimonidine. A literature search using the keywords Brimonidine in ophthalmology was performed using PubMed, Google Scholar, and IndMED. We screened titles, keywords and articles describing the use of Brimonidine, selected and reviewed. The clinical application of brimonidine in ophthalmology is extensive. When considering its application in clinical practice, one should be mindful of the indications, risks, and its benefits. In our review, we have noted that topical brimonidine, apart from its routine usage to reduce intraocular pressure, it is a novel therapy used in higher order aberrations, dysphtopsias postrefractive surgery, ocular congestion, to reduce bleeding in ophthalmic surgery, and to treat facial erythema, a dermatological manifestation of rosacea.

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Novel Anti-Inflammatory Effects of Brimonidine on Propionibacterium acnes-Induced Inflammatory Reaction

Cited by 2 publications

References 9 publications

Antibacterial Activity of Dr. Ridz Anti-Acne Nanoserum® Against Skin Bacteria That Cause Acne Vulgaris

Antibacterial Activity of Dr. Ridz Anti-Acne Nanoserum® Against Skin Bacteria That Cause Acne Vulgaris

Novel Uses of Brimonidine

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