2007
DOI: 10.1016/j.cbpb.2007.04.004
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Novel anti-inflammatory ω-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus

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Cited by 72 publications
(68 citation statements)
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“…PUFAs are considered essential for normal growth and development, which play an important role in the prevention and treatment of cardiovascular disease (Wang et al, 2006), hypertension (Narce et al, 1997), inflammation (Treschow et al, 2007), immune disorders (Kelley, 2001) and certain forms of cancer (Wigmore et al, 1996). However, PUFAs can be easily affected by adverse environmental conditions of light, moisture, free radicals and oxygen (Shahidi and Han, 1993).…”
Section: Introductionmentioning
confidence: 99%
“…PUFAs are considered essential for normal growth and development, which play an important role in the prevention and treatment of cardiovascular disease (Wang et al, 2006), hypertension (Narce et al, 1997), inflammation (Treschow et al, 2007), immune disorders (Kelley, 2001) and certain forms of cancer (Wigmore et al, 1996). However, PUFAs can be easily affected by adverse environmental conditions of light, moisture, free radicals and oxygen (Shahidi and Han, 1993).…”
Section: Introductionmentioning
confidence: 99%
“…It was found that this family of omega-3-PUFAs included C18:4, C19:4, C20:4, and C21:5 PUFAs (Treschow et al, 2007). The C20:4 fraction was the predominant PUFA in the extract, and was a structural isomer of arachidonic acid (AA) (Treschow et al, 2007). Further validation experiments are required to confirm if these PUFAs are indeed the active ingredients that confer the anti-inflammatory activities in vivo.…”
Section: Introductionmentioning
confidence: 95%
“…Inhibition of leukotriene production by stimulated human neutrophils was used as an in vitro screening method to test the anti-inflammatory activity of the purified PUFAs. It was found that this family of omega-3-PUFAs included C18:4, C19:4, C20:4, and C21:5 PUFAs (Treschow et al, 2007). The C20:4 fraction was the predominant PUFA in the extract, and was a structural isomer of arachidonic acid (AA) (Treschow et al, 2007).…”
Section: Introductionmentioning
confidence: 98%
“…Die langkettigen Omega-3-Fettsäuren spielen eine bedeutende Rolle bei der Prävention und Behandlung von Erkrankungen der Herzkranzgefäße (Calder, 2004 [Eicosapentaensäure und Docosahexaensäure]; Heidal et al, 2004;London et al, 2007), bei der Behandlung von Bluthochdruck (Ueshima et al, 2007), von Autoimmunerkrankungen (Kesavalu et al, 2007;Norris et al, 2007;Treschow et al, 2007), von Krebs (Kato et al, 2007) und von Augenkrankheiten (Connor et al, 2007;Seddon et al, 2006).…”
Section: Die "Wohltaten" Der Omega-3-fettsäurenunclassified