Novel antiangiogenic agents in dermatology

Berrios, Ricardo L.; Arbiser, Jack L.

doi:10.1016/j.abb.2010.12.016

Cited by 15 publications

(8 citation statements)

References 26 publications

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“…Although the cellular mechanisms were not characterized, it appears that the main SPF treatment effects we observed could be attributed to reduced wound retraction in the first 12 days followed by inhibition of exuberant granulation tissue, especially within the first 30 days of wound healing. It is known that excessive inflammation can impair wound healing, and ionic silver, gentian violet, and methylene blue have been proposed to have anti‐inflammatory effects . Gentian violet and methylene blue have antiangiogenic properties, which could conceivably impede exuberant granulation tissue formation.…”

Section: Discussionmentioning

confidence: 99%

A Preliminary Study of Silver Sodium Zirconium Phosphate Polyurethane Foam Wound Dressing on Wounds of the Distal Aspect of the Forelimb in Horses

Kelleher

Kilcoyne

Dechant³

et al. 2014

Veterinary Surgery

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The SPF wound dressing improved some measures of wound healing compared with the control dressing, most significantly during the first 30 days. This suggests that the SPF wound dressing may be useful in the early management of wounds on the equine lower limb. Further studies using the SPF dressing are needed to characterize the temporal and cellular effects on wound healing and evaluate this dressing in a clinical environment.

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Section: Discussionmentioning

confidence: 99%

A Preliminary Study of Silver Sodium Zirconium Phosphate Polyurethane Foam Wound Dressing on Wounds of the Distal Aspect of the Forelimb in Horses

Kelleher

Kilcoyne

Dechant³

et al. 2014

Veterinary Surgery

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“…Because secreted VEGF is a major angiogenic factor in glioma, VPA inhibition of VEGF secretion in vitro and VEGF expression in vivo in the VPA Inhibits Glioma Angiogenesis brain are important actions of indirect angiosuppression of VPA. 1,4) The direct mechanism represents a direct effect on endothelial cells in terms of endothelial cell proliferation and tube formation. Second, combination of other anti-angiogenic agents, such as metronomic CPT-11 treatment, enhanced the anti-angiogenic and anti-tumor effects of VPA.…”

Section: Discussionmentioning

confidence: 99%

Valproic Acid Inhibits Angiogenesis In Vitro and Glioma Angiogenesis In Vivo in the Brain

Osuka

Takano

Watanabe

et al. 2012

Neurol. Med. Chir.(Tokyo)

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Antiangiogenic strategy is promising for malignant glioma. Histone deacetylase inhibitors (HDACIs) are unique anticancer agents that exhibit antiangiogenic effects. The in vitro and in vivo antiangiogenic effects of HDACIs, valproic acid (VPA), were investigated in malignant glioma in the brain. In vitro, VPA preferentially inhibited endothelial cell proliferation compared to glioma cell proliferation at the optimum concentration in a dose-dependent manner. VPA reduced vascular endothelial growth factor (VEGF) secretion of glioma cells in a dose-dependent manner under both normoxic and hypoxic conditions. VPA was also found to inhibit tube formation in the angiogenesis assay. In vivo, treatment with VPA combined with irinotecan reduced the number of vessels expressing factor VIII in the brain tumor model. VPA inhibits glioma angiogenesis by direct (inhibition of endothelial cell proliferation and tube formation) and indirect (decreased secretion of VEGF by glioma cells) mechanisms. These data suggest a potential role for VPA as an adjuvant therapy for patients with malignant glioma.

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“…Studies show these compounds to be potent and efficacious inhibitors of Nox2 and Nox4 activity [61]. A structure-based approach to develop more specificity led to the synthesis of the fulvene derivatives class of inhibitors [62]. Fulvenes are aromatic molecules that have the advantage of being highly water soluble.…”

Section: Small Molecule Inhibitorsmentioning

confidence: 99%

NADPH oxidase inhibitors: a decade of discovery from Nox2ds to HTS

Cifuentes-Pagano

Csányi

Pagano

2012

Cell. Mol. Life Sci.

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NADPH oxidases (Nox) are established as major sources of reactive oxygen species (ROS). Over the past two decades, Nox-derived ROS have emerged as pivotal in the development of myriad diseases involving oxidative stress. In contrast, Nox are also involved in signaling mechanisms necessary for normal cell function. The study of these enzymes in physiological and pathophysiological conditions is made considerably more complex by the discovery of 7 isoforms: Nox1 through 5 as well as Duox1 and 2, each with its own specific cytosolic components, regulatory control mechanisms, subcellular localization and/or tissue distribution. A clear understanding of the role individual isoforms play in a given system is hindered by the lack of isoform-specific inhibitors. In animal models, knockdown or knockout methodologies are providing definitive answers to perplexing questions of the complex interplay of multiple Nox isoforms in cell and tissue signaling. However, the complex structures and interactions of these heteromeric isozymes predict pleiotropic actions of the Nox subunits and thus suppression of these proteins is almost certain to have untoward effects. Thus, as both therapies and pharmacological tools, molecule-based inhibitors continue to prove extremely useful and rational in design. Unfortunately, many of the available inhibitors have proven non-specific, falling into the category of scavengers or inhibitors of more than one source of ROS. Here, we will review some of the efforts that have been undertaken to develop specific inhibitors of NADPH oxidase over the past decade, from the peptidic inhibitor Nox2ds-tat to more recent small molecule inhibitors that have emerged from high-throughput screening campaigns.

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Novel antiangiogenic agents in dermatology

Cited by 15 publications

References 26 publications

A Preliminary Study of Silver Sodium Zirconium Phosphate Polyurethane Foam Wound Dressing on Wounds of the Distal Aspect of the Forelimb in Horses

A Preliminary Study of Silver Sodium Zirconium Phosphate Polyurethane Foam Wound Dressing on Wounds of the Distal Aspect of the Forelimb in Horses

Valproic Acid Inhibits Angiogenesis In Vitro and Glioma Angiogenesis In Vivo in the Brain

NADPH oxidase inhibitors: a decade of discovery from Nox2ds to HTS

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