Novel antibacterial dental resin containing silanized hydroxyapatite nanofibers with remineralization capability

Qin, Ludan; Yao, Shuo; Meng, Weixiao; Zhang, Jiajia; Shi, Ruirui; Zhou, Chuanjian; Wu, Junling

doi:10.1016/j.dental.2022.11.014

Cited by 15 publications

(8 citation statements)

References 56 publications

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“…Modification with 15-20% s-HAFs@EM showed a high antibacterial rate (>85%) [55] Hydrated calcium silicate (hCS)…”

Section: Streptococcus Mutansmentioning

confidence: 99%

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Antibacterial Agents Used in Modifications of Dental Resin Composites: A Systematic Review

Zalega,

Bociong

2024

Applied Sciences

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Introduction: Resin-based composites (RBCs) are very common and often applicable in dentistry. Their disadvantage is susceptibility to secondary caries due to the formation of bacterial biofilm at the interface with the patient’s tissues. Antimicrobial additive incorporation into RBCs seems to be a justified method to alleviate the above-mentioned negative phenomenon. The aim of this review is to provide a juxtaposition of strategies and results on the topic of antimicrobial composites. It also provides insights into future research and prospects for clinical applications. Methods: This review summarizes the literature from 2017 to 2024, describing potential antimicrobial agents incorporated into dental composites. The research methodology involved a systematic search using the Population/Intervention/Comparison/Outcome (PICO) structure and selecting articles from databases such as Pubmed, ScienceDirect, and Elsevier, which allowed for an in-depth review of substances utilized for the antibacterial modification of RBCs. Results: A total of 159 articles were identified, 43 of which met the inclusion criteria. Conclusions: This review is a summary of novel approaches in the field of dental materials science. The results show the variety of approaches to modifying composites for antimicrobial efficacy. It is worth underlining that there is a significant difficulty in comparing the studies selected for this review. This is related to the different modifiers used and the modification of composites with different compositions. Unfortunately, there is still a lack of a standardized approach to the modification of dental materials to give them a biocidal character and simultaneously maintain the stability of their mechanical and chemical properties.

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“…Modification with 15-20% s-HAFs@EM showed a high antibacterial rate (>85%) [55] Hydrated calcium silicate (hCS)…”

Section: Streptococcus Mutansmentioning

confidence: 99%

“…Qin et al [55] decided to enrich the composite material with potentially antibacterial silanized hydroxyapatite nanofibers loaded with erythromycin (s-HAFs@EM). The resin modified with 15% s-HAFs@EM exhibited the highest flexural strength and elastic modulus.…”

Section: Other Additivesmentioning

confidence: 99%

Antibacterial Agents Used in Modifications of Dental Resin Composites: A Systematic Review

Zalega,

Bociong

2024

Applied Sciences

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“…[26][27][28] Conversely, HA, being a primary component of dentin and enamel, [29][30][31] makes an excellent dental resin composite filler. [31][32][33] It provides mechanical strength, [34][35][36][37] is radiopaque, 38,39 and can even promote remineralization, [40][41][42] sealing microgaps between composites and teeth, [43][44][45] which may reduce future cavity risks. Therefore, recent years have seen an explosion of interest in advanced materials such as nanostructures and nanocomposites across various fields, including dental science.…”

Section: Introductionmentioning

confidence: 99%

Nanoflower hydroxyapatite's effect on the properties of resin‐based dental composite

Sağır,

Aydınoğlu,

Hazar Yoruç

2024

J of Applied Polymer Sci

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To investigate the reinforcing effect of nanoflower‐like hydroxyapatite (NFHA) in resin‐based dental composites, we synthesized a novel NFHA using microwave irradiation (MW), hydrothermal treatment (HT), and sonochemical synthesis (SS). Silanized NFHA was then used as the reinforcing filler in dental resin composites. We characterized the structure and morphology of various HA nanostructures using x‐ray diffraction, scanning electron microscope, and TEM. The mechanical performance of dental resin composites reinforced with silanized NFHA was measured using a universal testing machine. Spherical HA, synthesized through chemical precipitation (CP), served as the control group. One‐way analysis of variance was employed for the statistical analysis of the acquired data. The results demonstrate that the nanoflower morphology significantly was improved mechanical and physical properties. After conducting trials, the NFHA synthesized using MW and HT showed a substantial enhancement in mechanical and physical properties compared to the other structures. Therefore, it can be concluded that NFHA can serve as a novel reinforcing HA filler, providing regenerative properties to resin composites with sufficient mechanical strength.

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“…Previous studies have added antibacterial substances as fillers in order to effectively suppress the formation of biofilms and consequent DWLs. Recently, research strategies providing antibacterial properties by adding various metal nanoparticles to orthodontic resin cements have been considered [5,6]. Metal nanoparticles such as zinc oxide, Polymers 2023, 15, 2045 2 of 15 silver, titanium dioxide, calcium phosphate, and cerium oxide have an antibacterial effect, penetrating the cell membrane of attached bacteria and killing them.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Physicochemical Properties of Orthodontic Resin Cement Containing ZnO-Loaded Halloysite Nanotubes

2023

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Demineralized white lesions are a common problem when using orthodontic resin cement, which can be prevented with the addition of antibacterial substances. However, the addition of antibacterial substances such as zinc oxide alone may result in the deterioration of the resin cement’s functions. Halloysite nanotubes (HNTs) are known to be biocompatible without adversely affecting the mechanical properties of the material while having the ability to load different substances. The purpose of this study was to prepare orthodontic resin cement containing HNT fillers loaded with ZnO (ZnO/HNTs) and to investigate its mechanical, physical, chemical, and antibacterial properties. A group without filler was used as a control. Three groups containing 5 wt.% of HNTs, ZnO, and ZnO/HNTs were prepared. TEM and EDS measurements were carried out to confirm the morphological structure of the HNTs and the successful loading of ZnO onto the HNTs. The mechanical, physical, chemical, and antibacterial properties of the prepared orthodontic resin cement were considered. The ZnO group had high flexural strength and water absorption but a low depth of cure (p < 0.05). The ZnO/HNTs group showed the highest shear bond strength and film thickness (p < 0.05). In the antibacterial test, the ZnO/HNTs group resulted in a significant decrease in the biofilm’s metabolic activity compared to the other groups (p < 0.05). ZnO/HNTs did not affect cell viability. In addition, ZnO was cytotoxic at a concentration of 100% in the extract. The nanocomposite developed in this study exhibited antimicrobial activity against S. mutans while maintaining the mechanical, physical, and chemical properties of orthodontic resin cement. Therefore, it has the potential to be used as an orthodontic resin cement that can prevent DWLs.

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Novel antibacterial dental resin containing silanized hydroxyapatite nanofibers with remineralization capability

Cited by 15 publications

References 56 publications

Antibacterial Agents Used in Modifications of Dental Resin Composites: A Systematic Review

Antibacterial Agents Used in Modifications of Dental Resin Composites: A Systematic Review

Nanoflower hydroxyapatite's effect on the properties of resin‐based dental composite

Antibacterial and Physicochemical Properties of Orthodontic Resin Cement Containing ZnO-Loaded Halloysite Nanotubes

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