Novel antibacterial electrospun mats based on poly(d,l-lactide) nanofibers and zinc oxide nanoparticles

Electrospinning and electrospraying techniques for designing novel antibacterial poly(3-hydroxybutyrate)/zinc oxide nanofibrous composites

“…demonstrated by TEM that ZnO aggregation into PHB fibers was significant by increasing nanoparticles concentration; consequently, the surface area prone to act as biocide was probably diminished. In the case of S. aureus, there was a slight increase in AE with increasing ZnO concentrations, thus indicating a low resistance of this type of bacterium to ZnO nanoparticles, which could be due to structural and chemical compositional differences of the cell wall [12,38,39]. On the other hand, taking into account the norm employed for antibacterial tests, electrospun/ electrosprayed PHB-based fibers exhibited AE values (from 1.20 to 1.40), unsuitable for bactericidal mats against E. coli.…”

“…Nonetheless, these morphological features entail a huge inconvenient, namely, the adhesion of pathogenic microorganisms [5][6][7]. Several strategies have been developed in order to overcome this problematic issue, being the most prominent the incorporation of organic compounds [8], and more recently, metallic nanoparticles [9][10][11][12] with well-recognized antimicrobial properties. Electrospun polymer composites containing these specific nanoparticles can exhibit several advantages compared to typical organic compound-loaded polymers, such as higher thermal stability, enhanced mechanical performance or biocompatibility, depending on the chemical nature of nanoparticles [1,2,[12][13][14][15].…”

“…However, the electrospinning/electrospraying tandem technique has scarcely been explored as an approach for designing biocompatible and/or biodegradable mats with antibacterial properties. Parallel investigations were carried out by Rodrí-guez-Tobías et al [12] and Virovska et al [26] in which the influence of the fabrication technique, i.e., electrospinning or electrospinning/electrospraying, on the antibacterial activity of polylactide/ZnO fibers was investigated. The former authors reported a high inhibition growth (up to 94 % after 24 h of incubation) for S. aureus, when the electrospinning/electrospraying tandem approach was used for the fabrication of PLA fibers with 1 wt% electrosprayed ZnO nanoparticles.…”

Damage of lipopolysaccharides in outer cell membrane and production of ROS-mediated stress within bacteria makes nano zinc oxide a bactericidal agent

“…The ability to withstand harsh processing, its high durability in comparison with organic materials made it suitable for development of a stable antibacterial agent (Anagnostakos et al 2008). A handful of literatures are available on the antibacterial activity of ZNP (Sawai 2003;Jones et al 2008;Mitra et al 2012;Augustine et al 2014a, b;Rodríguez-Tobías et al 2014). A size-dependant bactericidal activity of ZNP has also been noted .…”

Biodegradable polymeric nanomaterials

“…Moreover, they may accelerate the healing process by promoting the migration of cells on the wound surface, and may also reduce wound contraction leading to a decrease in patient morbidity [77,85]. Finally, due to the ease of nanoparticle incorporation within the nanofibres, antimicrobial wound dressings may be further developed [70].…”