Novel Antibacterial Materials and Coatings—A Perspective by the Editors

Haidari, Hanif; Vasilev, Krasimir

doi:10.3390/ma16186302

Cited by 1 publication

(1 citation statement)

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“…Some innovative antimicrobial materials and methods can simultaneously target various types of bacteria, fungi, and even viruses. This broad-spectrum capability allows for a more comprehensive inhibition of pathogen growth during the antimicrobial process, thereby reducing the problem of drug resistance. , The adoption of innovative antimicrobial mechanisms or methods targeting multiple points can reduce bacterial adaptability to specific treatments. One promising approach is photodynamic therapy, a method that uses specific wavelengths of light to irradiate and, through the energy of light or the properties of photosensitive materials, eliminate or inhibit bacteria .…”

Section: Introductionmentioning

confidence: 99%

A Triple-Functional Antibacterial Platform Based on Quaternized Ru(II) Complex-Loaded MXene Composites

Zhou,

Zong,

Selim

et al. 2024

ACS Appl. Nano Mater.

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The problem of antibiotic misuse leading to bacterial resistance is a significant challenge currently faced. The rapid adaptability and evolutionary capabilities of microorganisms have caused strains that were initially sensitive to antibiotics to gradually become resistant, posing a threat to traditional antibacterial treatments. Therefore, the search for antibacterial treatment methods, especially those less likely to induce resistance, has become crucial. Photodynamic antibacterial therapy is an emerging method with efficient antibacterial and selective effects, reducing the risk of resistance. A two-dimensional nanocomposite material, modified with quaternized ruthenium complexes on MXene, has been developed. The minimum inhibitory concentrations against Escherichia coli and Staphylococcus aureus were found to be 23.4 and 29.0 μg/mL, respectively, under xenon lamp irradiation with a light power intensity of 100 mW/cm 2 for 20 min. The bactericidal effects of the Q/Ru-MXene composite system were quantitatively and qualitatively confirmed through plate counting and live/dead staining. This system integrates the chemical antibacterial properties of quaternary ammonium salts, the photodynamic antibacterial effects of ruthenium complexes, and the photothermal antibacterial properties of MXene. The simultaneous application of these three therapeutic approaches allows for the development of a chemical/photodynamic/ photothermal antibacterial strategy that can attack bacteria on multiple levels, enhancing treatment efficacy, slowing down the development of bacterial resistance, and adapting better to different types of infections. Research and the application of this comprehensive strategy have the potential to bring breakthroughs and innovations to the field of antibacterial treatment.

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Section: Introductionmentioning

confidence: 99%