Novel antibacterial ocular prostheses: Proof of concept and physico-chemical characterization

Baino, Francesco; Ferraris, Sara; Miola, Marta; Perero, Sergio; Verné, Enrica; Coggiola, Andrea; Dolcino, Daniela; Ferraris, Monica

doi:10.1016/j.msec.2015.11.075

Cited by 32 publications

(25 citation statements)

References 38 publications

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“…Furthermore, new deposition techniques for BG coatings will have to be developed and/or optimized to improve the coating performance [ 68 ]. In the last years, new approaches (e.g., multilayer BG coatings to achieve a good compromise between adequate TEC, slow dissolution rate, and bioactivity [ 69 ]) and fabrication methods (e.g., electrophoretic deposition [ 70 ], radio-frequency sputtering [ 71 ]) have been experimented to produce well-adherent and durable coatings on a variety of materials and implants, including scaffolds, suture wires, surgical screws, and ocular implants. At present, it is impossible to state that one strategy is clearly preferable to another, and further research remains to be performed.…”

Section: Grand Challenges For the Future—where Are We Going?mentioning

confidence: 99%

Bioactive Glasses: Where Are We and Where Are We Going?

Baino

Hamzehlou

Kargozar

2018

JFB

Self Cite

393

294

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Bioactive glasses caused a revolution in healthcare and paved the way for modern biomaterial-driven regenerative medicine. The first 45S5 glass composition, invented by Larry Hench fifty years ago, was able to bond to living bone and to stimulate osteogenesis through the release of biologically-active ions. 45S5-based glass products have been successfully implanted in millions of patients worldwide, mainly to repair bone and dental defects and, over the years, many other bioactive glass compositions have been proposed for innovative biomedical applications, such as soft tissue repair and drug delivery. The full potential of bioactive glasses seems still yet to be fulfilled, and many of today’s achievements were unthinkable when research began. As a result, the research involving bioactive glasses is highly stimulating and requires a cross-disciplinary collaboration among glass chemists, bioengineers, and clinicians. The present article provides a picture of the current clinical applications of bioactive glasses, and depicts six relevant challenges deserving to be tackled in the near future. We hope that this work can be useful to both early-stage researchers, who are moving with their first steps in the world of bioactive glasses, and experienced scientists, to stimulate discussion about future research and discover new applications for glass in medicine.

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Section: Grand Challenges For the Future—where Are We Going?mentioning

confidence: 99%

Bioactive Glasses: Where Are We and Where Are We Going?

Baino

Hamzehlou

Kargozar

2018

JFB

Self Cite

393

294

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“…Silver nanocluster/SiO 2 glass composite coatings have been also deposited via radio-frequency sputtering on the surface of poly(methyl methacrylate) (PMMA) ocular prostheses to be coupled with orbital implants (Figs. 4a-4c), and it was reported that the material elicited a potent antibacterial effect in vitro against Staphylococcus aureus due to the sustained release of Ag + ions [91,92].…”

Section: Ocular Applicationsmentioning

confidence: 99%

Glass-based coatings on biomedical implants: a state-of-the-art review

Baino¹,

Verné²

2017

Biomedical Glasses

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Bioactive glasses, invented by Prof. Larry L. Hench in the late 1960s, have revolutionized the field of biomaterials as they were shown to tightly bond to both hard and soft living tissues and to stimulate cells towards a path of regeneration and self-repair. However, due to their relatively poor mechanical properties (brittleness, low bending strength and fracture toughness), they are generally unsuitable for load-bearing applications. On the other hand, bioactive glasses have been successfully applied as coatings on the surface of stronger/tougher substrates to combine adequate mechanical properties with high bioactivity and, in some cases, additional extrafunctionalities (e.g. antibacterial properties, drug release). After giving a short overview of the main issues concerning the fabrication of glass coatings, this review provides a state-of-the-art picture in the field and specifically discusses the development of bioactive and hierarchical coatings on 3D porous scaffolds, joint prostheses, metallic substrates (e.g. wires or nails) for orthopedic fixation, polymeric meshes and sutures for wound healing, ocular implants and percutaneous devices.

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“…A severe complication during surgery and in the mid-term is the risk of implant-related infections; during the operation, the porous spheres are typically impregnated with antibiotic solutions that, however, exhibit a burst release and are ineffective against late infections [55]. Baino et al [56] tested the antibacterial efficacy of composite coatings made up of silver nanoclusters embedded in a silica matrix. These silver/silica coatings can be deposited on the orbital implant surface, as well as on the posterior surface of the PMMA prosthesis in contact with the patient's conjunctiva.…”

Section: Therapeutic Ion Release From Orbital Implants and Ocular Promentioning

confidence: 99%

Regulation of the Ocular Cell/Tissue Response by Implantable Biomaterials and Drug Delivery Systems

Baino

Kargozar

2020

Bioengineering

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Therapeutic advancements in the treatment of various ocular diseases is often linked to the development of efficient drug delivery systems (DDSs), which would allow a sustained release while maintaining therapeutic drug levels in the target tissues. In this way, ocular tissue/cell response can be properly modulated and designed in order to produce a therapeutic effect. An ideal ocular DDS should encapsulate and release the appropriate drug concentration to the target tissue (therapeutic but non-toxic level) while preserving drug functionality. Furthermore, a constant release is usually preferred, keeping the initial burst to a minimum. Different materials are used, modified, and combined in order to achieve a sustained drug release in both the anterior and posterior segments of the eye. After giving a picture of the different strategies adopted for ocular drug release, this review article provides an overview of the biomaterials that are used as drug carriers in the eye, including micro- and nanospheres, liposomes, hydrogels, and multi-material implants; the advantages and limitations of these DDSs are discussed in reference to the major ocular applications.

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Novel antibacterial ocular prostheses: Proof of concept and physico-chemical characterization

Cited by 32 publications

References 38 publications

Bioactive Glasses: Where Are We and Where Are We Going?

Bioactive Glasses: Where Are We and Where Are We Going?

Glass-based coatings on biomedical implants: a state-of-the-art review

Regulation of the Ocular Cell/Tissue Response by Implantable Biomaterials and Drug Delivery Systems

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