Novel anticancer agents in clinical and preclinical trials

Salim, Adnan

doi:10.18035/emj.v2i2.153

Cited by 1 publication

(2 citation statements)

References 19 publications

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“…As such, inappropriate activation of the canonical pathway may lead to elevated levels of intracellular β-catenin. This may occur as a result of mutations in β-catenin or other proteins in the pathway, overexpression of Wnt ligands and/or loss of inhibitors or regulatory proteins [ 10 ].…”

Section: Articlementioning

confidence: 99%

“…In conclusion, with the current era of advancements in anticancer therapeutics, therapies targeting the Wnt pathway do carry some significance [ 48 ]. However, it is worthwhile to note here that perturbations of the Wnt signalling pathway in normal cells can be lethal and it has been difficult to identify design specific inhibitory markers that could act on affected cells alone.…”

Section: Articlementioning

confidence: 99%

See 1 more Smart Citation

The role of Wnt signaling pathway in carcinogenesis and implications for anticancer therapeutics

Sheikh

Niazi²,

Ahmed

et al. 2014

Hered Cancer Clin Pract

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The Wnt proteins are a family of 19 secreted glycoproteins that occupy crucial roles in the regulation of processes such as cell survival, proliferation, migration and polarity, cell fate specification, body axis patterning and self-renewal in stem cells. The canonical pathway has been implicated in a variety of cancers. As such, it is only fair to conclude that therapies targeting the Wnt pathway may play an essential role in the future of anticancer therapeutics, both alone or in conjunction with traditional therapies.

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Section: Articlementioning

confidence: 99%

Section: Articlementioning

confidence: 99%