Novel Antimicrobial Cellulose Fleece Inhibits Growth of Human-Derived Biofilm-Forming Staphylococci During the SIRIUS19 Simulated Space Mission

Abstract

Wischer et al. Antimicrobial Coated Cellulose Inhibits Staphylococci and S. epidermidis) strongly dominated at all time points, most were resistant against erythromycin, kanamycin, and ampicillin. AGXX R coatings completely inhibited growth of these opportunistic pathogens on all tested surface materials. Particularly, AGXX Rcellulose fleece achieved a clear reduction in bacterial load able to recover post contact. GOX-cellulose fleece effectively immobilized bacteria. Sequence analysis of 16S rRNA gene amplicons revealed that the isolated Staphylococcus spp. did not dominate the overall bacterial community, accounting for only 0.1-0.4% of all sequences. Instead, molecular data revealed Lactobacillus, Comamonas, Pseudomonas, Sporosarcina, and Bacillus as the dominant genera across all samples and time points.

Antimicrobial and Antibiofilm Activity of the Probiotic Strain Streptococcus salivarius K12 against Oral Potential Pathogens

“…The cause of these diseases is mostly pathogenic bacteria found in the oral cavity. Potential oral pathogenic bacteria are able to form a biofilm, and such bacteria include Streptococcus mutans [6], Schaalia odontolytica [7], Staphylococcus hominis [8,9], and Enterobacter cloacae [10].…”

Graphene‐Based Bacterial Filtration via Electrostatic Adsorption

“…[19] Based on multivalent electrostatic attraction, these GO derivates (GOX) also showed antibacterial activity when they were attached to a carrier material. [20,21] Although many polycationic polymers like chitosan, [22,23] polyethylene imine, [24,25] ε-polylysine, [26] polysiloxanes, [27,28] polyionenes [29,30] as well as modified GO materials with various conjugated moieties like mannose, [31] lactose, [32] quaternary ammonium compounds [33,34] and zwitterionic systems [35] have been shown to bind and inhibit bacteria, investigation Flexible graphene oxide (GO) microsheets with attached positively charged polymers, termed GOX microsheets, are efficient at bacterial adsorption, as they bind electrostatically to bacterial membranes' negative surface charge. The authors explore an antimicrobial water filter application for GOX's extremely high surface area and its previously described efficient bacterial adsorption.…”