Novel antioxidant peptide from broken rice resist H2O2-induced premature senescence in 2BS cells via PI3K/Akt and JNK/Bax signaling pathway

Novel antioxidant peptides from sheep plasma protein hydrolysates: Purification, identification and cytoprotective effects against H2O2‐induced oxidative stress

“…Similarly, Ren et al. (2023) found that SGDWSDIGGR derived from broken rice hydrolysis products could significantly affect the number of H 2 O 2 ‐induced early apoptotic cells. Wu et al.…”

“…Moreover, the early apoptosis rate corresponding to 200 µmol/L WEEPAM was 6.99%, significantly lower than damaged group (25.16%, p > 0.05). Similarly, Ren et al (2023) found that SGDWSDIGGR derived from broken rice hydrolysis products could significantly affect the number of H 2 O 2induced early apoptotic cells. Wu et al (2020) showed that MTTNL and MTTNI peptides derived from shrimp protein hydrolysate significantly inhibited scopolamine-induced early apoptosis.…”

Preparation, identification and molecular docking of two novel anti-aging peptides from perilla seed

“…The utilization of the membrane permeation probe DCFH-DA, which undergoes oxidation by intracellular ROS resulting in the production of intensely fluorescent DCF in proportion to ROS levels, was employed to evaluate the efficacy of synthetic peptide in inhibiting ROS generation [ 53 ]. Following treatment with H 2 O 2 , the level of reactive oxygen species (ROS) in HaCaT cells exhibited a statistically significant increase of 1.81 ± 0.08 times compared to the control group (p < 0.001).…”

“…6 . The increase in antioxidant enzymes brought on by the Keap1-Nrf2 pathway's activation may be the reason for the decrease in ROS in the NFF and PMR treatment groups [ 53 ]. However, cellular senescence is closely related to ROS accumulation [ 53 ].…”

“…The increase in antioxidant enzymes brought on by the Keap1-Nrf2 pathway's activation may be the reason for the decrease in ROS in the NFF and PMR treatment groups [ 53 ]. However, cellular senescence is closely related to ROS accumulation [ 53 ]. This discovery implies that NFF and PMR possess the potential to mitigate the detrimental effects of reactive oxygen species (ROS) on aging and injury.…”