Novel antiparasitic diterpenoids and development of a potential drug delivery system for targeting leishmania infected macrophages

Kayser, Oliver; Kiderlen, AF; Siems, Karsten

doi:10.1016/s1383-5769(98)80646-6

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unfortunately, both proved to have toxic effects of therapeutic doses [88]. A series of 80 labdane derivatives showed significant antileishmanial activity ( L. donovani, L. enriettii, L. major, L. infantum), but cytotoxicity increased in parallel with the antiprotozoal effect [89]. From structure-activity studies overbridged tri-or tetracyclic ring labdanes had more significant activity in comparison to bicyclic labdanes.…”

Section: Diterpenesmentioning

confidence: 99%

Natural products as potential antiparasitic drugs

Kayser

Kiderlen

Croft

2002

Studies in Natural Products Chemistry

View full text Add to dashboard Cite

Pharmaceutical research in natural products represents a major strategy for discovering and developing new drugs. The use of medicinal plants for the treatment of parasitic diseases is well known and documented since ancient times e.g. by the use of Cinchona succiruba (Rubiaceae) as an antimalarial. This chapter provides a comprehensive review of the latest results in the field of antiparasitic drug development from biologic sources (plants, bacteria, fungi and marine organisms) focussing on the treatment of protozoal infections (Plasmodium, Leishmania, Trypanosoma spp.). The status of validated in vitro and in vivo assays is reviewed, discussing their different features, problems and limitations. Because of the high number of natural products tested against the aforesaid protozoa in the last years, we limit the discussion to lignans, phenolics, terpenoids, and alkaloids as defined natural product classes. The review also covers essential research topics of recent publications on specific natural products (e.g. licochalcone A, benzyl-and naphthylisoquinoline alkaloids, and artemisinin) and gives an outlook to semisynthetic approaches of drugs already introduced in clinics or in clinical trial studies.

show abstract

Section: Diterpenesmentioning

confidence: 99%